Characterization of lidocaine:hydroxypropyl-β-cyclodextrin inclusion complex

被引：37
|
作者：
Moraes, Carolina Morales
Abrami, Priscila
de Araujo, Daniele Riberio
Braga, Angelica F. A.
Issa, Michelle Georges
Ferraz, Humberto G.
de Paula, Eneida
Fraceto, Leonardo Fernandes
机构：
[1] Univ Sorocaba, Dept Farm, BR-18023000 Sorocaba, SP, Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Bioquim, BR-13081970 Campinas, SP, Brazil
[3] Univ Sao Paulo, Dept Farm, FC Farmaceut, BR-05508 Sao Paulo, Brazil
[4] Univ Estadual Campinas, FC Med, Dept Anestesiol, BR-13081970 Campinas, SP, Brazil
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2007年 / 57卷 / 1-4期
关键词：
lidocaine; HP-beta-CD; HPLC; association constant; thermodynamic parameters;
D O I：
10.1007/s10847-006-9179-x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An inclusion complex was prepared between the local anesthetic lidocaine (LDC) and hydroxypropyl-beta-CD (HP-beta-CD). The complex was characterized by thermal analysis (differential scanning calorimetry, DSC), UV absorption and high-pressure liquid chromatography (HPLC). DSC results were indicative of complexation, due to the loss of the characteristic endothermic peak of LDC (77 degrees C). Phase-solubility diagrams allowed the determination of the association constant between LDC and HP-beta-CD (35.7 +/- 4.7 M-1). The rate of LDC release decreased after complexation and thermodynamic parameters from the HPLC studies (Delta G degrees = -2.65 kJ/mol) revealed that a stable complex was formed.
引用
收藏
页码：313 / 316
页数：4
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