Characterization of lidocaine:hydroxypropyl-β-cyclodextrin inclusion complex

被引：36
作者：
Moraes, Carolina Morales
Abrami, Priscila
de Araujo, Daniele Riberio
Braga, Angelica F. A.
Issa, Michelle Georges
Ferraz, Humberto G.
de Paula, Eneida
Fraceto, Leonardo Fernandes
机构：
[1] Univ Sorocaba, Dept Farm, BR-18023000 Sorocaba, SP, Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Bioquim, BR-13081970 Campinas, SP, Brazil
[3] Univ Sao Paulo, Dept Farm, FC Farmaceut, BR-05508 Sao Paulo, Brazil
[4] Univ Estadual Campinas, FC Med, Dept Anestesiol, BR-13081970 Campinas, SP, Brazil
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2007年 / 57卷 / 1-4期
关键词：
lidocaine; HP-beta-CD; HPLC; association constant; thermodynamic parameters;
D O I：
10.1007/s10847-006-9179-x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An inclusion complex was prepared between the local anesthetic lidocaine (LDC) and hydroxypropyl-beta-CD (HP-beta-CD). The complex was characterized by thermal analysis (differential scanning calorimetry, DSC), UV absorption and high-pressure liquid chromatography (HPLC). DSC results were indicative of complexation, due to the loss of the characteristic endothermic peak of LDC (77 degrees C). Phase-solubility diagrams allowed the determination of the association constant between LDC and HP-beta-CD (35.7 +/- 4.7 M-1). The rate of LDC release decreased after complexation and thermodynamic parameters from the HPLC studies (Delta G degrees = -2.65 kJ/mol) revealed that a stable complex was formed.
引用
收藏
页码：313 / 316
页数：4
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