New insights on CRISPR/Cas9-based therapy for breast Cancer

被引：16

作者：

Sabit, Hussein ^{[1
]}

Abdel-Ghany, Shaimaa ^{[2
]}

Tombuloglu, Huseyin ^{[1
]}

Cevik, Emre ^{[1
]}

Alqosaibi, Amany ^{[3
]}

Almulhim, Fatma ^{[4
]}

Al-Muhanaa, Afnan ^{[4
]}

机构：

[1] Imam Abdulrahman Bin Faisal Univ, Inst Med Res & Consultat, Dept Genet, POB 1982, Dammam 31441, Saudi Arabia

[2] Misr Univ Sci & Technol, Coll Biotechnol, Dept Environm Biotechnol, POB 77, Giza, Egypt

[3] Imam Abdulrahman Bin Faisal Univ, Dept Biol, Coll Sci, PO 4 Box, Dammam 1982, Saudi Arabia

[4] Imam Abdulrahman Bin Faisal Univ, Breast Imaging Div, KFHU, PO 4 Box, Dammam 1982, Saudi Arabia

来源：

GENES AND ENVIRONMENT | 2021年 / 43卷 / 01期

关键词：

CRISPR/Cas9; Genome editing; Breast Cancer; Therapy; RESTRICTION ENZYMES; COLORECTAL-CANCER; GENE; RNA; CRISPR-CAS9; CLEAVAGE; DELIVERY; SYSTEM; NUCLEASES; MODEL;

D O I：

10.1186/s41021-021-00188-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

CRISPR/Cas9 has revolutionized genome-editing techniques in various biological fields including human cancer research. Cancer is a multi-step process that encompasses the accumulation of mutations that result in the hallmark of the malignant state. The goal of cancer research is to identify these mutations and correlate them with the underlying tumorigenic process. Using CRISPR/Cas9 tool, specific mutations responsible for cancer initiation and/or progression could be corrected at least in animal models as a first step towards translational applications. In the present article, we review various novel strategies that employed CRISPR/Cas9 to treat breast cancer in both in vitro and in vivo systems.

引用

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