Dependence of rat hippocampal c-Fos expression on intensity and duration of exercise

被引：47

作者：

Lee, TH

Jang, MH

Shin, MC

Lim, BV

Kim, YP

Kim, H

Choi, HH

Lee, KS

Kim, EH

Kim, CJ

机构：

[1] Kyung Hee Univ, Dept Physiol, Coll Med, Dongdaemoon Gu, Seoul 130701, South Korea

[2] Kyung Hee Univ, Res Inst Phys Educ, Seoul 130701, South Korea

[3] Univ Incheon, Res Inst Sports Sci, Inchon, South Korea

[4] Semyung Univ, Coll Oriental Med, Dept Meridianol, Jechon, South Korea

来源：

LIFE SCIENCES | 2003年 / 72卷 / 12期

关键词：

treadmill exercise; c-Fos; exercise intensity; exercise duration; immunohistochemistry;

D O I：

10.1016/S0024-3205(02)02406-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The expression of c-Fos, an immediately early gene, is a marker of neural activity. In the present study, the effect of treadmill exercise on c-Fos expression was investigated in various regions of the rat hippocampus via immunohistochemistry. The first part of the experiment was aimed at determining the dependence of c-Fos expression on the intensity of treadmill exercise. In most of the hippocampal regions studied, increasing c-Fos expression was observed with increasing exercise intensity. In the second part of the experiment, the dependence of c-Fos expression on the duration of treadmill exercise was investigated. The c-Fos expression induced by mild-intensity exercise increased until the 7th day of exercise and subsequently decreased. Results of the present study suggest that the effect of treadmill exercise on neuronal activity in the hippocampus is intensity-and duration-dependent. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：1421 / 1436

页数：16

共 46 条

[1] Exercise influences spatial learning in the radial arm maze [J].