Photoreceptor inner and outer segment layer thickness inmultiple evanescent white dot syndrome

被引:11
作者
Arai, Rei [1 ]
Kimura, Itaru [1 ,2 ]
Imamura, Yutaka [3 ]
Shinoda, Kei [4 ]
Matsumoto, Celso Soiti [4 ]
Seki, Keisuke [4 ]
Ishida, Masahiro [3 ]
Murakami, Akira [5 ]
Mizota, Atsushi [4 ]
机构
[1] Juntendo Univ, Urayasu Hosp, Dept Ophthalmol, Chiba, Japan
[2] Natl Inst Sensory Organs, Tokyo Med Ctr, Natl Hosp Org, Lab Neurobiol,Div Mol & Cellular Biol, Tokyo, Japan
[3] Teikyo Univ, Sch Med, Dept Ophthalmol, Univ Hosp Mizonokuchi, Sagamihara, Kanagawa, Japan
[4] Teikyo Univ, Sch Med, Dept Ophthalmol, Itabashi Ku, Tokyo 1730003, Japan
[5] Juntendo Univ, Sch Med, Dept Ophthalmol, Tokyo 113, Japan
关键词
Multiple evanescent white dot syndrome; Photoreceptor inner and outer segment; Cone outer segment tips; Multifocal electroretinogram; Optical coherence tomography; OPTICAL COHERENCE TOMOGRAPHY; KOYANAGI-HARADA-DISEASE; MULTIPLE; ABNORMALITIES;
D O I
10.1007/s00417-014-2747-7
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose To evaluate the photoreceptor inner and outer segment layer thickness in eyes with MEWDS. Design Prospective, non-comparative, observational case series. The follow-up duration was 4 months. Methods Four women were diagnosed with unilateral MEWDS. The ages of the patients were 25, 24, 35, and 40 years. The retinal microstructure was assessed by spectral-domain optical coherence tomography (SD-OCT). The thickness of the photoreceptor inner (IS) and outer (OS) segments and sum of them (IS + OS) at the fovea were analyzed. Results The visual acuity was reduced in three of four eyes at the acute phase. SD-OCT showed that the border of IS and OS (IS/OS) line and the cone outer segment tips (COST) line in the macula area were not detected in all four eyes. The IS + OS thickness was 50.3 +/- 5.6 mu m and that of the healthy fellow eyes was 73.5 +/- 7.0 mu m (n = 4 eyes). The thickness of the IS was 27.8 +/- 2.6 mu m and that of the OS was 45.8 +/- 7.3 mu m. In all eyes, there was a spontaneous improvement of the visual acuity. SD-OCT showed a recovery of only the IS/OS line in the macular area, but the COST line was not visible in three cases. The mean IS + OS thickness increased to 56.0 +/- 7.9 mu m (n = 4), IS = 26.0 +/- 2.0 mu m (n = 3), and OS = 30.1 +/- 8.7 mu m (n = 3) in the early recovery phase, and to 64.8 +/- 9.3 mu m (n = 4), IS= 28.5 +/- 1.7 mu m (n = 4), and OS = 36.3 +/- 7.9 mu m (n = 4) in the late recovery phase. The mean inner and outer segment thickness remained unchanged in the fellow eyes. Conclusion Eyes with MEWDS have changes in the photoreceptor microstructures. The change in the IS + OS thickness during the natural recovery course might be due to an increase in the OS length.
引用
收藏
页码:1645 / 1651
页数:7
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