Tetrahydrobiopterin - Regulator of endothelial nitric oxide synthase in vascular disease

被引：152

作者：

Channon, KM ^{[1
]}

机构：

[1] Univ Oxford, Dept Cardiovasc Med, John Radcliffe Hosp, Oxford OX3 9DU, England

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2004年 / 14卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tcm.2004.10.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vascular disease states such as atherosclerosis and diabetes, endothelial nitric oxide (NO) bioactivity is reduced and oxidative stress is increased, resulting in endothelial dysfunction. Recent studies suggest that changes in the activity and regulation of endothelial NO synthase by its cofactor tetrahydrobiopterin (BH4) is an important contributor to endothelial dysfunction. Pharmacologic studies and more recent insights from genetically modified mouse models have improved the understanding of the mechanistic role and importance of BH4 in vascular disease pathogenesis. Targeting BH4 may provide new therapeutic strategies in vascular disease. (C) 2004, Elsevier Inc.

引用

页码：323 / 327

页数：5

共 31 条

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