Antibody responses in hyperthyroid rats

被引：10

作者：

Bittencourt, C. S. ^{[1
]}

Azzolini, A. E. C. S. ^{[1
]}

Ferreira, D. A. ^{[1
]}

Assis-Pandochi, A. I. ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Quim & Fis, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, Brazil

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2007年 / 7卷 / 07期

关键词：

T-3; thyroid hormones; hyperthyroidism; antibody response;

D O I：

10.1016/j.intimp.2007.02.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study evaluated antibody production against sheep red blood cells (SRBC) in hyperthyroid rats during treatment with triiodothyronine (TA The immune response was evaluated by measuring plaque forming cells (PFC) in the spleen and by enzyme-linked immunosorbent assay (ELISA) in serum of male Wistar rats (180 +/- 10 g) treated with 25 mu g/day of triiodotironine (T-3) during 7-12 days and immunized with SRBC at the 8th day of treatment. The results showed that anti-SRBC antibody production was significantly decreased in animals treated for 12 days when compared to normal rats immunized with the same antigen, as evaluated by the two assays. These results show that in this experimental model hyperthyroidism decreases antibody response. We previously observed the opposite effect, that is, an increase in this response in hypothyroid rats resulting from the treatment with propylthyouracil, a blocker of thyroid hormone biosynthesis. It is suggested that antibody production is affected by thyroid hormone levels. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：989 / 993

页数：5

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