Clonal Expansion of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis, Japan

被引：27

作者：

Murase, Yoshiro ^{[1
]}

Maeda, Shinji ^{[1
]}

Yamada, Hiroyuki ^{[1
]}

Ohkado, Akihiro ^{[1
]}

Chikamatsu, Kinuyo ^{[1
]}

Mizuno, Kazue ^{[1
]}

Kato, Seiya ^{[1
]}

Mitarai, Satoshi ^{[1
]}

机构：

[1] Japan AntiTB Assoc, Mol Epidemiol Div, Res Inst TB, Tokyo, Japan

来源：

EMERGING INFECTIOUS DISEASES | 2010年 / 16卷 / 06期

关键词：

MYCOBACTERIUM-TUBERCULOSIS; TANDEM REPEATS; EPIDEMIOLOGY; POPULATION; IDENTIFICATION; AFRICA; LOCI; IRAN;

D O I：

10.3201/eid1606.091844

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The emergence and spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has raised public health concern about global control of TB. To estimate the transmission dynamics of MDR and XDR TB, we conducted a DNA fingerprinting analysis of 55 MDR/XDR Mycobacterium tuberculosis strains isolated from TB patients throughout Japan in 2002. Twenty-one (38%) of the strains were classified into 9 clusters with geographic links, which suggests that community transmission of MDR/XDR TB is ongoing. Furthermore, the XDR M. tuberculosis strains were more likely than the non XDR MDR strains to be clustered (71% vs. 24%; p = 0.003), suggesting that transmission plays a critical role in the new incidence of XDR TB. These findings highlight the difficulty of preventing community transmission of XDR TB by conventional TB control programs and indicate an urgent need for a more appropriate strategy to contain highly developed drug-resistant TB.

引用

页码：948 / 954

页数：7