Still stratus not altocumulus: Further evidence against the date/party hub distinction

被引：85

作者：

Batada, Nizar N. ^{[1
]}

Reguly, Teresa

Breitkreutz, Ashton

Boucher, Lorrie

Breitkreutz, Bobby-Joe

Hurst, Laurence D.

Tyers, Mike

机构：

[1] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

[2] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[3] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON, Canada

来源：

PLOS BIOLOGY | 2007年 / 5卷 / 06期

关键词：

EVOLUTIONARY; ARCHITECTURE; MODULARITY;

D O I：

10.1371/journal.pbio.0050154

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the new filtered-HC dataset, as in others, the two definitional criteria of date/party hubs find no support. Four corollary points of evidence - rate of evolution, effect of deletion on network topology, genetic connectivity, and hub status quo - also find no support. That across multiple datasets, and under multiple different tests, we repeatedly find no evidence for the date/party hypothesis suggests that network hubs do not fall into discrete classes. © 2007 Batada et al.

引用

页码：1202 / 1206

页数：5

共 15 条

[1] Evolutionary and physiological importance of hub proteins [J].

Batada, Nizar N. ;

Hurst, Laurence D. ;

Tyers, Mike .

PLOS COMPUTATIONAL BIOLOGY, 2006, 2 (07) :748-756

[2] Stratus not altocumulus: A new view of the yeast protein interaction network [J].

Batada, Nizar N. ;

Reguly, Teresa ;

Breitkreutz, Ashton ;

Boucher, Lorrie ;

Breitkreutz, Bobby-Joe ;

Hurst, Laurence D. ;

Tyers, Mike .

PLOS BIOLOGY, 2006, 4 (10) :1720-1731

[3] Why highly expressed proteins evolve slowly [J].

Drummond, DA ;

Bloom, JD ;

Adami, C ;

Wilke, CO ;

Arnold, FH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (40) :14338-14343

[4] Modularity and evolutionary constraint on proteins [J].

Fraser H.B. .

Nature Genetics, 2005, 37 (4) :351-352

[5] Proteome survey reveals modularity of the yeast cell machinery [J].

Gavin, AC ;

Aloy, P ;

Grandi, P ;

Krause, R ;

Boesche, M ;

Marzioch, M ;

Rau, C ;

Jensen, LJ ;

Bastuck, S ;

Dümpelfeld, B ;

Edelmann, A ;

Heurtier, MA ;

Hoffman, V ;

Hoefert, C ;

Klein, K ;

Hudak, M ;

Michon, AM ;

Schelder, M ;

Schirle, M ;

Remor, M ;

Rudi, T ;

Hooper, S ;

Bauer, A ;

Bouwmeester, T ;

Casari, G ;

Drewes, G ;

Neubauer, G ;

Rick, JM ;

Kuster, B ;

Bork, P ;

Russell, RB ;

Superti-Furga, G .

NATURE, 2006, 440 (7084) :631-636

[6] Functional organization of the yeast proteome by systematic analysis of protein complexes [J].

Gavin, AC ;

Bösche, M ;

Krause, R ;

Grandi, P ;

Marzioch, M ;

Bauer, A ;

Schultz, J ;

Rick, JM ;

Michon, AM ;

Cruciat, CM ;

Remor, M ;

Höfert, C ;

Schelder, M ;

Brajenovic, M ;

Ruffner, H ;

Merino, A ;

Klein, K ;

Hudak, M ;

Dickson, D ;

Rudi, T ;

Gnau, V ;

Bauch, A ;

Bastuck, S ;

Huhse, B ;

Leutwein, C ;

Heurtier, MA ;

Copley, RR ;

Edelmann, A ;

Querfurth, E ;

Rybin, V ;

Drewes, G ;

Raida, M ;

Bouwmeester, T ;

Bork, P ;

Seraphin, B ;

Kuster, B ;

Neubauer, G ;

Superti-Furga, G .

NATURE, 2002, 415 (6868) :141-147

[7] Evidence for dynamically organized modularity in the yeast protein-protein interaction network [J].

Han, JDJ ;

Bertin, N ;

Hao, T ;

Goldberg, DS ;

Berriz, GF ;

Zhang, LV ;

Dupuy, D ;

Walhout, AJM ;

Cusick, ME ;

Roth, FP ;

Vidal, M .

NATURE, 2004, 430 (6995) :88-93

[8] THE DIP TEST OF UNIMODALITY [J].

HARTIGAN, JA ;

HARTIGAN, PM .

ANNALS OF STATISTICS, 1985, 13 (01) :70-84

[9]

HARTIGAN PM, 1985, J R STAT SOC C-APPL, V34, P320

[10] Adjusting for selection on synonymous sites in estimates of evolutionary distance [J].

Hirsh, AE ;

Fraser, HB ;

Wall, DP .

MOLECULAR BIOLOGY AND EVOLUTION, 2005, 22 (01) :174-177

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