A general procedure for carbon isotope labeling of linear urea derivatives with carbon dioxide

被引：22

作者：

Babin, Victor ^{[1
]}

Sallustrau, Antoine ^{[1
]}

Loreau, Olivier ^{[1
]}

Caille, Fabien ^{[2
]}

Goudet, Amelie ^{[1
]}

Cahuzac, Heloise ^{[3
]}

Del Vecchio, Antonio ^{[1
]}

Taran, Frederic ^{[1
]}

Audisio, Davide ^{[1
]}

机构：

[1] Univ Paris Saclay, CEA Serv Chim Bioorgan & Marquage, DMTS, F-91191 Gif Sur Yvette, France

[2] Univ Paris Saclay, INSERM, CNRS, CEA,Lab Imagerie Biomed Multimodale Paris Saclay, F-91401 Orsay, France

[3] Univ Paris Saclay, Dept Medicaments & Technol Sante DMTS, CEA, INRAE,SIMoS, F-91191 Gif Sur Yvette, France

来源：

CHEMICAL COMMUNICATIONS | 2021年 / 57卷 / 54期

基金：

欧盟地平线“2020”;

关键词：

BINDING-PROTEIN; 4; EFFICIENT SYNTHESIS; DRUG DISCOVERY; CARBONYLATION; C-11; RADIOSYNTHESIS;

D O I：

10.1039/d1cc02665h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbon isotope labeling is a traceless technology, which allows tracking the fate of organic compounds either in the environment or in living organisms. This article reports on a general approach to label urea derivatives with all carbon isotopes, including C-14 and C-11, based on a Staudinger aza-Wittig sequence. It provides access to all aliphatic/aromatic urea combinations.

引用

页码：6680 / 6683

页数：4

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