Endogenous expression of c-Fos in hypothalamic nuclei of neonatal rabbits coincides with their circadian pattern of suckling-associated arousal

被引:41
作者
Allingham, K
von Saldern, C
Brennan, PA
Distel, H
Hudson, R
机构
[1] Univ Munich, Inst Med Psychol, D-80336 Munich, Germany
[2] Univ Cambridge, Subdept Anim Behav, Cambridge CB3 8AA, England
[3] Natl Autonomous Univ Mexico, Inst Invest Biomed, Mexico City 04510, DF, Mexico
关键词
circadian rhythms; feeding-entrained anticipatory activity; c-Fos; neonatal rabbits; supraoptic nucleus; paraventricular hypothalamic nucleus;
D O I
10.1016/S0006-8993(97)01379-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rabbits exhibit an unusually restricted form of maternal care. The newborn young are only nursed for about 3 min every 24 h and drink up to one third of their body weight in this time. They show a circadian increase in activity in anticipation of the doe's visit, which is entrained by suckling and appears analogous to feeding-entrained rhythms reported for other species. By investigating the expression of c-Fos protein in nursed and un-nursed pups at selected times before and after scheduled nursing, we were able to distinguish endogenous patterns of neuronal activation and patterns induced by suckling. Increased endogenous expression of c-Fos in the paraventricular thalamus and in the magnocellular neurons of the paraventricular hypothalamus coincided with the period of anticipatory arousal. By contrast, suckling induced c-Fos expression in the supraoptic nucleus and the parvocellular neurons of the paraventricular hypothalamus, whilst decreasing expression in the magnocellular neurons. Furthermore, the endogenous pattern of c-Fos expression was less distinct in 3-day-old compared to 7-day-old pups, suggesting maturational or experience-related influences on the neural correlates of the anticipatory arousal. In conclusion, the close correspondence between c-Fos expression and pups' endogenous rhythm of behaviour suggests that the rabbit's natural schedule of restricted nursing provides an ideal model in which to investigate the ontogeny of circadian function without disrupting the mother-offspring relationship or normal neonatal development. (C) 1998 Elsevier Science B.V.
引用
收藏
页码:210 / 218
页数:9
相关论文
共 41 条
[1]   ANTICIPATORY ACTIVITY AND ENTRAINMENT OF CIRCADIAN-RHYTHMS IN SYRIAN-HAMSTERS EXPOSED TO RESTRICTED PALATABLE DIETS [J].
ABE, H ;
RUSAK, B .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (01) :R116-R124
[2]   ACTIVITY OF OXYTOCINERGIC NEURONS IN THE PARAVENTRICULAR NUCLEUS MIRRORS THE PERIODICITY OF THE ENDOGENOUS STIMULATORY RHYTHM REGULATING PROLACTIN SECRETION [J].
AREY, BJ ;
FREEMAN, ME .
ENDOCRINOLOGY, 1992, 130 (01) :126-132
[3]   ARE GLIA AMONG THE CELLS THAT EXPRESS IMMUNOREACTIVE C-FOS IN THE SUPRACHIASMATIC NUCLEUS [J].
BENNETT, MR ;
SCHWARTZ, WJ .
NEUROREPORT, 1994, 5 (14) :1737-1740
[4]  
BROEKHUIZEN S, 1983, ACTA ZOOL FENN, V174, P61
[5]   DIURNAL-VARIATION IN VASOPRESSIN AND OXYTOCIN MESSENGER-RNAS IN HYPOTHALAMIC NUCLEI OF THE RAT [J].
BURBACH, JPH ;
LIU, B ;
VOORHUIS, TAM ;
VANTOL, HHM .
MOLECULAR BRAIN RESEARCH, 1988, 4 (02) :157-160
[6]   EFFECTS OF VAGOTOMY ON ENTRAINMENT OF ACTIVITY RHYTHMS TO FOOD ACCESS [J].
COMPERATORE, CA ;
STEPHAN, FK .
PHYSIOLOGY & BEHAVIOR, 1990, 47 (04) :671-678
[7]   Neuroanatomical characterization of Fos induction in rat behavioral models of anxiety [J].
Duncan, GE ;
Knapp, DJ ;
Breese, GR .
BRAIN RESEARCH, 1996, 713 (1-2) :79-91
[9]   REGIONAL EXPRESSION OF C-FOS ANTIGEN IN THE BASAL FOREBRAIN FOLLOWING INTRAVENTRICULAR INFUSIONS OF ANGIOTENSIN AND ITS MODULATION BY DRINKING EITHER WATER OR SALINE [J].
HERBERT, J ;
FORSLING, ML ;
HOWES, SR ;
STACEY, PM ;
SHIERS, HM .
NEUROSCIENCE, 1992, 51 (04) :867-882
[10]   THE PATTERN OF BEHAVIOR OF RABBIT PUPS IN THE NEST [J].
HUDSON, R ;
DISTEL, H .
BEHAVIOUR, 1982, 79 :255-&