Dynamic Hydrogels: Switching of 3D Microenvironments Using Two-Component Naturally Derived Extracellular Matrices

被引：128

作者：

Gillette, Brian M. ^{[1
]}

Jensen, Jacob A. ^{[1
]}

Wang, Meixin ^{[1
]}

Tchao, Jason ^{[1
]}

Sia, Samuel K. ^{[1
]}

机构：

[1] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 06期

关键词：

IN-VITRO; STEM-CELLS; COLLAGEN; MIGRATION; NETWORKS; PROLIFERATION; MORPHOGENESIS; ENCAPSULATION; MICROSCOPY; SCAFFOLDS;

D O I：

10.1002/adma.200902265

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article describes fabrication of a two-component extracellular matrix (ECM) in which one component acts as a stable structural element and another component gels or dissolves reversibly (a modulatory component). Using a composite collagen-alginate ECM, reversible cross-linking of the alginate (the modulatory component) via application of calcium or citrate modulates cell mobility in a 3D collagen matrix (the structural component)

引用

页码：686 / +

页数：7

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