Dynamic Hydrogels: Switching of 3D Microenvironments Using Two-Component Naturally Derived Extracellular Matrices

被引：128
作者：
Gillette, Brian M. [1 ]
Jensen, Jacob A. [1 ]
Wang, Meixin [1 ]
Tchao, Jason [1 ]
Sia, Samuel K. [1 ]
机构：
[1] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA
来源：
ADVANCED MATERIALS | 2010年 / 22卷 / 06期
关键词：
IN-VITRO; STEM-CELLS; COLLAGEN; MIGRATION; NETWORKS; PROLIFERATION; MORPHOGENESIS; ENCAPSULATION; MICROSCOPY; SCAFFOLDS;
D O I：
10.1002/adma.200902265
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This article describes fabrication of a two-component extracellular matrix (ECM) in which one component acts as a stable structural element and another component gels or dissolves reversibly (a modulatory component). Using a composite collagen-alginate ECM, reversible cross-linking of the alginate (the modulatory component) via application of calcium or citrate modulates cell mobility in a 3D collagen matrix (the structural component)
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收藏
页码：686 / +
页数：7
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