Effects of a Ruthenium Schiff Base Complex on Glucose Homeostasis in Diet-Induced Pre-Diabetic Rats

被引:18
作者
Mabuza, Lindokuhle Patience [1 ]
Gamede, Mlindeli Wilkinson [1 ]
Maikoo, Sanam [2 ]
Booysen, Irvin Noel [2 ]
Ngubane, Phikelelani Siphosethu [1 ]
Khathi, Andile [1 ]
机构
[1] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Coll Hlth Sci, ZA-4000 Durban, South Africa
[2] Univ KwaZulu Natal, Sch Chem & Phys, Coll Agr & Environm Sci, ZA-3209 Pietermaritzburg, South Africa
来源
MOLECULES | 2018年 / 23卷 / 07期
基金
新加坡国家研究基金会;
关键词
pre-diabetes; ruthenium complex; glycated haemoglobin; dietary intervention; INSULIN SENSITIVITY; DIABETES PREVENTION; ENERGY HOMEOSTASIS; HIGH-FRUCTOSE; LEPTIN; THERAPY; RISK; COMPLICATIONS; INTERVENTION; METABOLISM;
D O I
10.3390/molecules23071721
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pre-diabetes is a condition that precedes type 2 diabetes mellitus (T2DM) that is characterised by elevated glycated haemoglobin (HbA1c). The management of pre-diabetes includes the combination of dietary and pharmacological interventions to increase insulin sensitivity. However, poor patient compliance has been reported with regard to dietary interventions, therefore, new alternative drugs are required that can be effective even without the dietary intervention. In our laboratory, we have synthesised a novel ruthenium complex that has been shown to have elevated biological activity. This study investigated the effects of this complex in both the presence and absence of dietary intervention on glucose handling in a diet-induced pre-diabetes rat model. Pre-diabetic animals were randomly assigned to respective treatment groups. The ruthenium complex was administered to pre-diabetic rats once a day every third day for 12 weeks. The administration of the ruthenium complex resulted in reduced fasting blood glucose, food intake, and body weight gain which was associated with decreased plasma ghrelin, insulin, and HbA1c levels in both the presence and absence of dietary intervention. The administration of the ruthenium complex ameliorated glycaemic control and insulin sensitivity in pre-diabetic rats. The results of this study warrant further investigations as this compound could potentially be able to re-sensitize insulin resistant cells and reduce the incidence of T2DM.
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页数:11
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