Once weeklyfluoxetine, tolerability and safety according to use patterns in the psychiatric clinical practice

被引:0
作者
González, ALM
de la Gándara, J
Fernández, SM
Fernández, FMV
Varona, A
机构
[1] Hosp Univ Salamanca, Dept Psiquiat, Salamanca, Spain
[2] Hosp Divino Valles, Dept Psiquiatria, Burgos, Spain
来源
ACTAS ESPANOLAS DE PSIQUIATRIA | 2004年 / 32卷 / 05期
关键词
once weekly fluoxetine; depression; tolerability; safety; antidepressant; use pattern;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Introduction. Treatment with selective serotonin reuptake inhibitors (SSRI) has become generalized in all the medical setting although its efficacy and good tolerability may be affected by long term non-compliance. Once weekly fluoxetine could improve compliance due to the comfort of its use. The objective is to evaluate the safety, tolerability and efficacy of once weekly fluoxetine (90 mg) in a sample of out-patients, following naturalistic criteria in the usual clinical practice. Method. A total of 46 patients (age: 41.89 +/- 1.85) who received once weekly fluoxetine for at least 3 months (mean time: 135.24 days) were analyzed retrospectively. Clinical Global Impression of Severity (CGI-S) at the onset and end of the period evaluated, presence of adverse events, drop-out index and impression of patient's satisfaction with the treatment and use pattern were used. Results. The mean of the final CGI-S was 2.09, compared with the onset 3.09 (p < 0.02), indicating significant improvement in the efficacy with once weekly fluoxetine. The most frequent adverse effects were: anxiety (10.87%), headache (8.69%) and restlessness (8,69%) related with once weekly fluoxetine. Compliance was very high at the onset (99%) and at the end (96%). Ten patients dropped-out of the treatment (27.74%), 6 due to appearance of undesirable effects (anxiety, headache and insomnia), three due to voluntary wish and only one due to lack of efficacy. The CGI of satisfaction of clinical global efficacy on the final visit was 1.43 (satisfied-very satisfied) and the CGI of satisfaction for the treatment pattern was 1.17 (very satisfied). Conclusion. Change to once weekly fluoxetine generally improves satisfaction of treatment efficacy and its use pattern, although some patients return to the initial regime after adverse effects appear.
引用
收藏
页码:280 / 286
页数:7
相关论文
共 17 条
  • [1] Patient compliance to a new enteric-coated weekly formulation of fluoxetine during continuation treatment of major depressive disorder
    Claxton, A
    de Klerk, E
    Parry, M
    Robinson, JM
    Schmidt, ME
    [J]. JOURNAL OF CLINICAL PSYCHIATRY, 2000, 61 (12) : 928 - 932
  • [2] de Klerk E, 2001, J CLIN PSYCHIAT, V62, P43
  • [3] Delgado PL, 2000, J CLIN PSYCHIAT, V61, P6
  • [4] Risk factors and predictors of compliance in depression
    Demyttenaere, K
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2003, 13 : S69 - S75
  • [5] SSRI antidepressant use patterns and their relation to clinical global impression scores: a naturalistic study
    Hylan, TR
    Meneades, L
    Crown, WH
    Sacristan, JA
    Gilaberte, I
    Montejo, AL
    [J]. JOURNAL OF AFFECTIVE DISORDERS, 1999, 52 (1-3) : 111 - 119
  • [6] Kupfer DJ, 2001, J CLIN PSYCHIAT, V62, P3
  • [7] Lin EHB, 1999, AM J PSYCHIAT, V156, P643
  • [8] Tolerability and adherence issues in antidepressant therapy
    Masand, PS
    [J]. CLINICAL THERAPEUTICS, 2003, 25 (08) : 2289 - 2304
  • [9] Switching patients from daily citalopram, paroxetine, or sertraline to once-weekly fluoxetine in the maintenance of response for depression
    Miner, CM
    Brown, EB
    Gonzales, JS
    Munir, R
    [J]. JOURNAL OF CLINICAL PSYCHIATRY, 2002, 63 (03) : 232 - 240
  • [10] Patient adherence in the treatment of depression
    Pampallona, S
    Bollini, P
    Tibaldi, G
    Kupelnick, B
    Munizza, C
    [J]. BRITISH JOURNAL OF PSYCHIATRY, 2002, 180 : 104 - 109