Modification of polyprenol by phosphorylation and acylation

被引：0
|
作者：
Malenkovskaya, M. A. [1 ]
Rasadkina, E. N. [1 ]
Pugashova, N. P. [1 ]
机构：
[1] Moscow State Pedag Univ, Inst Biol & Chem, Nesvizhskii Per 3, Moscow 119021, Russia
来源：
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 52卷 / 01期
关键词：
Phosphonate; Hydrophosphoryl; Carboxylic Acid Chloride; Prenol; Hexaethyl;
D O I：
10.1134/S1070428016010036
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Polyprenol isolated from spruce needles was subjected to phosphorylation and acylation. Its phosphorylation with hexaethylphosphorous triamide in dioxane afforded bis(polyprenyl) N,N-diethylphosphoramidite which was hydrolyzed to bis(polyprenyl) phosphonate. The latter can be used in the synthesis of prodrugs. The acylation of polyprenol with aromatic and heterocyclic carboxylic acid chlorides gave the corresponding esters as potential precursors of pharmacologically important compounds. The structure of the isolated compounds was confirmed by H-1, P-31, and C-13 NMR and IR spectra.
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页码：11 / 14
页数：4
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