Hepatoid Carcinoma of the Pancreas Combined with Neuroendocrine Carcinoma

被引:25
作者
Jung, Ji Ye [1 ]
Kim, Yoon Jae [1 ]
Kim, Hee Man [1 ]
Kim, Hong Jeoung [1 ]
Park, Seun Woo [1 ]
Song, Si Young [1 ]
Chung, Jae Bock [1 ]
Kang, Chang Moo [2 ]
Pyo, Joo Yeon [3 ]
Yang, Woo Ick [3 ]
Bang, Seungmin [1 ]
机构
[1] Yonsei Univ, Div Gastroenterol, Coll Med, Inst Gastroenterol,Dept Internal Med, Seoul 120752, South Korea
[2] Yonsei Univ, Dept Gen Surg, Coll Med, Seoul 120752, South Korea
[3] Yonsei Univ, Dept Pathol, Coll Med, Seoul 120752, South Korea
关键词
Hepatoid carcinoma; Pancreas; Neuroendocrine carcinoma; ALPHA-FETOPROTEIN; DIFFERENTIATION; STOMACH; ADENOCARCINOMA; HEPATOCYTES; CANCER; CELLS; AFP;
D O I
10.5009/gnl.2010.4.1.98
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatoid carcinoma is a primary extrahepatic carcinoma whose morphology, immunohistochemistry, and behavior are similar to those of hepatocellular Garcinoma. The most common sites of extrahepatic carcinoma are the stomach and ovary, but nine cases of hepatocellular differentiation of the pancreas have been reported in the literature. We report another case of hepatoid carcinoma of the pancreas that was associated with the development of a pancreatic endocrine carcinoma in a 46-year-old man. Serum alpha-fetoprotein (AFP) was elevated to 262.49 IU/mL and radiological examinations revealed a mass measuring 7.5 cm in diameter in the head of the pancreas. He underwent a conventional Whipple operation, and light microscopy showed adenocarcinoma that was immunopositive for AFP, hepatocyte antigen, cytokeratin, chromogranin, synaptophysin, and alpha-1 antichymotrypsin. Although hepatoid differentiation was not shown unequivocally histologically, other immunohistochemistry findings supported the diagnosis of hepatoid carcinoma combined with neuroendocrine carcinoma. The patient was healthy and had no evidence of recurrence at 4 months after the surgery. This report describes why hepatoid carcinoma should be considered as a differential diagnosis of a pancreatic mass, especially when serum AFP is elevated. (Gut Liver 2010;4:98-102)
引用
收藏
页码:98 / 102
页数:5
相关论文
共 22 条
[1]  
DELORIMIER A, 1993, CANCER, V71, P293, DOI 10.1002/1097-0142(19930115)71:2<293::AID-CNCR2820710204>3.0.CO
[2]  
2-O
[3]  
GITLIN D, 1972, CANCER RES, V32, P979
[4]   Hepatoid carcinoma of the pancreas - A case report and literature review of a heterogeneous group of tumors [J].
Hameed, Omar ;
Xu, Haodong ;
Saddeghi, Saha ;
Maluf, Horacio .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2007, 31 (01) :146-152
[5]   A NEOPLASM WITH PANCREATIC AND HEPATOCELLULAR DIFFERENTIATION PRESENTING WITH SUBCUTANEOUS FAT NECROSIS [J].
HRUBAN, RH ;
MOLINA, JM ;
REDDY, MN ;
BOITNOTT, JK .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1987, 88 (05) :639-645
[6]  
Hughes K, 2004, AM SURGEON, V70, P1030
[7]  
ISHIKURA H, 1985, CANCER-AM CANCER SOC, V56, P840, DOI 10.1002/1097-0142(19850815)56:4<840::AID-CNCR2820560423>3.0.CO
[8]  
2-E
[9]  
ISHIKURA H, 1986, CANCER-AM CANCER SOC, V58, P119, DOI 10.1002/1097-0142(19860701)58:1<119::AID-CNCR2820580121>3.0.CO
[10]  
2-U