Interleukin-6 inhibition and cardiovascular disease in patients with rheumatoid arthritis

被引：2
作者：
Popkova, T. V. [1 ]
Novikova, D. S. [1 ]
Nasonov, E. L. [1 ]
机构：
[1] VA Nasonova Res Inst Rheumatol, Moscow, Russia
来源：
TERAPEVTICHESKII ARKHIV | 2016年 / 88卷 / 05期
关键词：
rheumatoid arthritis; biological agents; risk for cardiovascular events; IL-6 receptor inhibition; CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; RANDOMIZED CONTROLLED-TRIAL; IL-6 RECEPTOR INHIBITION; HIGH-DENSITY-LIPOPROTEIN; NECROSIS-FACTOR-ALPHA; RISK-FACTORS; TOCILIZUMAB MONOTHERAPY; DOUBLE-BLIND; CIRCULATING INTERLEUKIN-6;
D O I：
10.17116/terarkh201688593-101
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Rheumatoid arthritis (RA) is a disease conferring a high risk for cardiovascular events (CVE). Systemic inflammation underlying RA favors the development of CVE. The safety of biological agents acting on the cardiovascular system has been inadequately investigated. On the one hand, they decrease RA activity and, on the other, may increase the risk of CVE. This review analyzes the literature data predominantly published in recent years on the effect of an IL-6 receptor inhibitor on the cardiovascular system. Tocilizumab is shown to be a promising agent to reduce cardiovascular risk. The findings need to be clinically verified. Long-term prospective investigations should be conducted to determine more exactly the impact of IL-6 receptor inhibition on the development of CVE.
引用
收藏
页码：93 / 101
页数：9
相关论文
共 91 条
[1]   Statins as antiinflammatory and immunomodulatory agents - A future in rheumatologic therapy? [J].
Abeles, AM ;
Pillinger, MH .
ARTHRITIS AND RHEUMATISM, 2006, 54 (02) :393-407
[2]   Influence of interleukin-6 G-174C gene polymorphism on coronary artery disease, cardiovascular complications and mortality in dialysis patients [J].
Aker, Sendogan ;
Bantis, Christos ;
Reis, Philip ;
Kuhr, Nicola ;
Schwandt, Christina ;
Grabensee, Bernd ;
Heering, Peter ;
Ivens, Katrin .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (09) :2847-2851
[3]   Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women [J].
Bermudez, EA ;
Rifai, N ;
Buring, J ;
Manson, JE ;
Ridker, PA .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (10) :1668-1673
[4]   Targeting cardiovascular risk in rheumatoid arthritis: a dual role for statins [J].
Bisoendial, Radjesh J. ;
Stroes, Erik S. G. ;
Kastelein, John J. P. ;
Tak, Paul Peter .
NATURE REVIEWS RHEUMATOLOGY, 2010, 6 (03) :157-164
[5]   The Role of Traditional Cardiovascular Risk Factors Among Patients with Rheumatoid Arthritis [J].
Brady, Sharmayne R. E. ;
de Courten, Barbora ;
Reid, Christopher M. ;
Cicuttini, Flavia M. ;
de Courten, Maximilian P. J. ;
Liew, Danny .
JOURNAL OF RHEUMATOLOGY, 2009, 36 (01) :34-40
[6]   Interleukin-6 gene -174G > C and -572G > C promoter polymorphisms are strong predictors of plasma -: Interleukin-6 levels after coronary artery bypass surgery [J].
Brull, DJ ;
Montgomery, HE ;
Sanders, J ;
Dhamrait, S ;
Luong, L ;
Rumley, A ;
Lowe, GDO ;
Humphries, SE .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (09) :1458-1463
[7]  
Burger Danielle, 2002, Autoimmunity Reviews, V1, P111, DOI 10.1016/S1568-9972(01)00018-0
[8]   Cholesterol efflux by high density lipoproteins is impaired in patients with active rheumatoid arthritis [J].
Charles-Schoeman, Christina ;
Lee, Yuen Yin ;
Grijalva, Victor ;
Amjadi, Sogol ;
FitzGerald, John ;
Ranganath, Veena K. ;
Taylor, Mihaela ;
McMahon, Maureen ;
Paulus, Harold E. ;
Reddy, Srinivasa T. .
ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (07) :1157-1162
[9]   Significant effects of biologic therapy on lipid profiles and insulin resistance in patients with rheumatoid arthritis [J].
Chen, Der-Yuan ;
Chen, Yi-Ming ;
Hsieh, Tsu-Yi ;
Hsieh, Chia-Wei ;
Lin, Chi-Chen ;
Lan, Joung-Liang .
ARTHRITIS RESEARCH & THERAPY, 2015, 17
[10]   Protective function of tocilizumab in human cardiac myocytes ischemia reperfusion injury [J].
Chengi, Hai Feng ;
Feng, Yan ;
Jiang, Da-Ming ;
Tao, Kai Yu ;
Kong, Min-Jian .
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, 2015, 8 (01) :48-52
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