HLAs in Autoimmune Diseases: Dependable Diagnostic Biomarkers?

被引：21

作者：

Rajaei, Elham ^{[1
]}

Jalali, Mohammad Taha ^{[2
]}

Shahrabi, Saeid ^{[3
]}

Asnafi, Ali Amin ^{[4
]}

Pezeshki, Seyed Mohammad Sadegh ^{[4
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Golestan Hosp, Clin Res Dev Unit, Ahvaz, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Hyperlipidemia Res Ctr, Diabet Res Ctr, Ahvaz, Iran

[3] Semnan Univ Med Sci, Fac Med, Dept Biochem & Hematol, Semnan, Iran

[4] Ahvaz Jundishapur Univ Med Sci, Thalassemia & Hemoglobinopathy Res Ctr, Hlth Res Inst, Ahvaz, Iran

来源：

CURRENT RHEUMATOLOGY REVIEWS | 2019年 / 15卷 / 04期

关键词：

Human leukocyte antigen; Behcet's syndrome; Rheumatoid arthritis; Systemic lupus erythematosus; Type; 1; diabetes; Celiac disease; Autoimmunity; HUMAN-LEUKOCYTE ANTIGEN; CLASS-I; BEHCETS-DISEASE; CELIAC-DISEASE; SUSCEPTIBILITY; RISK; ASSOCIATIONS; EXPRESSION; AGE; DQ;

D O I：

10.2174/1573397115666190115143226

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The process of antigen presentation to immune cells is an undeniable contributor to the pathogenesis of autoimmune diseases. Different studies have indicated several factors that are related to autoimmunity. Human Leukocyte Antigens (HLAs) are among such factors, which have a key role in autoimmunity because of their involvement in antigen presentation process. Methods: Relevant English language literature was searched and retrieved from Google Scholar search engine and PubMed database (1996-2018). The following keywords were used: "Human leukocyte antigen", "Behcet's syndrome", "Rheumatoid arthritis", "Systemic lupus erythematosus", "Type 1 diabetes", "Celiac Disease" and "Autoimmunity". Results: There is a strong association between HLA alleles and autoimmune diseases. For instance, HLA-B alleles and Behcet's syndrome are strongly correlated, and systemic lupus erythematosus and Type 1 diabetes are related to I HLA-DQA1 and HLA-DQB1, respectively. Conclusion: Association between numerous HLA alleles and autoimmune diseases may justify and rationalize their use as biomarkers as well as possible diagnostic laboratory parameters.

引用

页码：269 / 276

页数：8

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