Non-high-density lipoprotein cholesterol versus low-density lipoprotein cholesterol in clinical practice: ANMCO position paper

被引：14

作者：

Colivicchi, Furio ^{[1
]}

Di Fusco, Stefania Angela ^{[1
]}

Arca, Marcello ^{[2
]}

Leggio, Massimo ^{[1
]}

Caldarola, Pasquale ^{[3
]}

Murrone, Adriano ^{[4
]}

Valente, Serafina ^{[5
]}

Urbinati, Stefano ^{[6
]}

Roncon, Loris ^{[7
]}

Amodeo, Vincenzo ^{[8
]}

Aspromonte, Nadia ^{[9
]}

Cipriani, Manlio ^{[10
]}

Domenicucci, Stefano ^{[11
]}

Francese, Giuseppina Maura ^{[12
]}

Imazio, Massimo ^{[13
]}

di Uccio, Fortunato Scotto ^{[14
]}

Di Lenarda, Andrea ^{[15
]}

Gulizia, Michele Massimo ^{[12
,16
]}

Gabrielli, Domenico ^{[17
]}

机构：

[1] San Filippo Neri Hosp ASL Roma 1, Clin & Rehabilitat Cardiol Unit, Rome, Italy

[2] Sapienza Univ Roma, Dept Translat & Precis Med, Rome, Italy

[3] San Paolo Hosp, UOC Cardiol UTIC, Bari, Italy

[4] Osped Citta Castello & Gubbio Gualdo Tadino, Cardil Intens Care Unit, Azienda USL Umbria 1, Perugia, Italy

[5] Le Scotte Univ Hosp, Cardiol Dept, Siena, Italy

[6] AUSL Bologna, Bellaria Hosp, Cardiol Unit, Bologna, Italy

[7] Osped Santa Maria Misericordia, Cardiol Unit, Rovigo, Italy

[8] Santa Maria Ungheresi Hosp, Cardil Intens Care Unit, Reggio Di Calabria, Italy

[9] Fdn Policlin Univ A Gemelli IRCCS, Dept Cardiovasc & Thorac Sci, Rome, Italy

[10] ASST Grande Osped Metropolitano Niguarda Ca Grand, Cardiol Unit 2, Milan, Italy

[11] Osped Padre A Micone, ASL 3, Cardiol Unit, Genoa, Italy

[12] Osped Garibaldi Nesima, Azienda Rilievo Nazl & Alta Specializzaz Garibald, Cardiol Div, Catania, Italy

[13] AOU Citta Salute & Sci Torino, Presidio Molinette, Cardil Unit, Turin, Italy

[14] Osped Mare Napoli, Cardiol UTIC Emodinam, Naples, Italy

[15] Univ Hosp & Hlth Serv Trieste, Cardiovasc Ctr, Trieste, Italy

[16] Heart Care Fdn, Fdn Tuo Cuore, Florence, Italy

[17] Augusto Murri Hosp, Div Cardiol, Fermo, Italy

来源：

JOURNAL OF CARDIOVASCULAR MEDICINE | 2021年 / 22卷 / 08期

关键词：

cardiovascular risk; cholesterol; low-density lipoprotein cholesterol; non-high-density lipoprotein cholesterol; therapeutic target; NON-HDL CHOLESTEROL; CORONARY-HEART-DISEASE; APOLIPOPROTEIN-B; LDL-CHOLESTEROL; CARDIOVASCULAR-DISEASE; REDUCING LIPIDS; RISK; METAANALYSIS; EFFICACY; SAFETY;

D O I：

10.2459/JCM.0000000000001175

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Bloodstream cholesterol is a central contributor to atherosclerotic cardiovascular diseases. For several decades, low-density lipoprotein cholesterol (LDL-C) has been the main biomarker for the prediction of cardiovascular events and therapeutic target of lipid-lowering treatments. More recently, several findings have supported the greater reliability of non-high-density lipoprotein cholesterol (non-HDL-C) as a predictive factor and possible therapeutic target in refining antiatherogenic treatments, especially among patients with lower LDL-C and higher triglyceride values. This article discusses the limits of current standard methods for assessing LDL-C levels and emphasizes the persistent residual cardiovascular risk in patients treated with lipid-lowering agents on the basis of recommended LDL-C targets. It highlights that patients with controlled LDL-C and non-targeted non-HDL-C have a higher cardiovascular risk. The article focuses on the role of non-HDL-C as a better predictor of atherosclerotic disease as compared with LDL-C and as a therapeutic target. Finally, this article includes an executive summary aimed at refining preventive approaches in atherosclerotic cardiovascular disease.

引用

页码：609 / 617

页数：9

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