Clinical proteomics-driven precision medicine for targeted cancer therapy: current overview and future perspectives

被引：36
作者：
Zhou, Li [1 ,2 ,3 ,4 ]
Wang, Kui [1 ,2 ,3 ]
Li, Qifu [4 ]
Nice, Edouard C. [1 ,2 ,3 ,5 ]
Zhang, Haiyuan [4 ]
Huang, Canhua [1 ,2 ,3 ,4 ]
机构：
[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610064, Peoples R China
[2] Sichuan Univ, West China Hosp, Ctr Canc, Chengdu 610064, Peoples R China
[3] Collaborat Innovat Ctr Biotherapy, Chengdu, Peoples R China
[4] Hainan Med Coll, Affiliated Hosp, Dept Neurol, 31 Longhua Rd, Haikou, Hainan, Peoples R China
[5] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic, Australia
来源：
EXPERT REVIEW OF PROTEOMICS | 2016年 / 13卷 / 04期
基金：
中国国家自然科学基金;
关键词：
cancer therapy; mass spectrometry; Clinical proteomics; drug target identification; precision medicine; SPECTROMETRY-BASED PROTEOMICS; IMAGING MASS-SPECTROMETRY; MOLECULAR PATHOLOGICAL EPIDEMIOLOGY; LASER CAPTURE MICRODISSECTION; LABEL-FREE DETECTION; CELL LUNG-CANCER; BIOMARKER DISCOVERY; LIQUID-CHROMATOGRAPHY; LC-MS/MS; CHEMICAL PROTEOMICS;
D O I：
10.1586/14789450.2016.1159959
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer is a common disease that is a leading cause of death worldwide. Currently, early detection and novel therapeutic strategies are urgently needed for more effective management of cancer. Importantly, protein profiling using clinical proteomic strategies, with spectacular sensitivity and precision, offer excellent promise for the identification of potential biomarkers that would direct the development of targeted therapeutic anticancer drugs for precision medicine. In particular, clinical sample sources, including tumor tissues and body fluids (blood, feces, urine and saliva), have been widely investigated using modern high-throughput mass spectrometry-based proteomic approaches combined with bioinformatic analysis, to pursue the possibilities of precision medicine for targeted cancer therapy. Discussed in this review are the current advantages and limitations of clinical proteomics, the available strategies of clinical proteomics for the management of precision medicine, as well as the challenges and future perspectives of clinical proteomics-driven precision medicine for targeted cancer therapy.
引用
收藏
页码：367 / 381
页数：15
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