Piperitone from Mentha longifolia var. chorodictya Rech F. reduces the nitrofurantoin resistance of strains of Enterobacteriaceae

被引：33
作者：
Shahverdi, AR [1 ]
Rafii, F
Tavassoli, F
Bagheri, M
Attar, F
Ghahraman, A
机构：
[1] Univ Tehran, Fac Pharm, Dept Pharmaceut Biotechnol, Tehran 14174, Iran
[2] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA
[3] Azarbaijan Med Plants Res Ctr, Ardebil, Iran
[4] Univ Tehran, Cent Herbarium, Fac Sci, Tehran, Iran
来源：
PHYTOTHERAPY RESEARCH | 2004年 / 18卷 / 11期
关键词：
Mentha longifolia; nitrofurantoin; piperitone; essential oils; Enterobacteria;
D O I：
10.1002/ptr.1566
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The diluted essential oil of Mentha longifolia (L.) var. chlorodictya Rech F. foliage enhanced the bactericidal activity of nitrofurantoin decreasing the minimum inhibitory concentration (MIC) of nitrofurantoin for nitrofurantoin-resistant strains of Enterobacteriaceae. Thin-layer chromatography (TLC) analysis of the essential oil detected a fraction (R-f = 0.35, UV lambda(MAX) of 232.5), which was the most effective in enhancement of nitrofurantoin activity. Using gas liquid chromatography and known standards, the active fraction was identified as piperitone. 1mul of the piperitone fraction decreased the MIC of nitrofurantoin 3-20 fold for the different strains of Enterobacteriaceae tested. Copyright (C) 2004 John Wiley Sons, Ltd.
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收藏
页码：911 / 914
页数：4
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