Unconventional Secretion of Plant Extracellular Vesicles and Their Benefits to Human Health: A Mini Review

被引：8
作者：
Farley, Joshua T. [1 ]
Eldahshoury, Mahmoud K. [1 ]
de Marcos Lousa, Carine [1 ,2 ]
机构：
[1] Leeds Beckett Univ, Sch Hlth, Biomed Sci, Leeds, England
[2] Univ Leeds, Ctr Plant Sci, Leeds, England
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷
关键词：
extracellular vesicles; unconventional protein secretion (UPS); plant EVs; biomedicine; biopharming; exosomes; ENZYME REPLACEMENT THERAPY; BIOLOGICAL-PROPERTIES; PROTEIN SECRETION; DELIVERY; CELLS; GLUCOCEREBROSIDASE; NANOPARTICLES; NANOVESICLES; ARABIDOPSIS; MICRORNAS;
D O I：
10.3389/fcell.2022.883841
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mechanisms devoted to the secretion of proteins via extracellular vesicles (EVs) have been found in mammals, yeasts, and plants. Since they transport a number of leader-less proteins to the plasma membrane or the extracellular space, EVs are considered part of Unconventional protein secretion (UPS) routes. UPS involving EVs are a relatively new field in plants. Aside from their role in plant physiology and immunity, plant extracts containing EVs have also been shown to be beneficial for human health. Therefore, exploring the use of plant EVs in biomedicine and their potential as drug delivery tools is an exciting avenue. Here we give a summary of the state of knowledge on plant EVs, their crosstalk with mammalian systems and potential research routes that could lead to practical applications in therapeutic drug delivery.
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页数：7
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