Imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy

被引：15

作者：

Asai, Takuya ^{[1
]}

Liu, Hanqin ^{[1
]}

Ozeki, Yasuyuki ^{[1
]}

Sato, Shinichi ^{[2
]}

Hayashi, Tomohiro ^{[3
,4
]}

Nakamura, Hiroyuki ^{[2
]}

机构：

[1] Univ Tokyo, Dept Elect Engn & Informat Syst, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan

[2] Tokyo Inst Technol, Inst Innovat Res, Lab Chem & Life Sci, Midori Ku, 4259 Nagatsuta Cho, Yokohama, Kanagawa 2268503, Japan

[3] Tokyo Inst Technol, Sch Mat & Chem Technol, Midori Ku, 4259 Nagatsuta Cho, Yokohama, Kanagawa 2268502, Japan

[4] JST PRESTO, 4-1-8 Hon Cho, Kawaguchi, Saitama 3320012, Japan

来源：

APPLIED PHYSICS EXPRESS | 2019年 / 12卷 / 11期

关键词：

NEUTRON-CAPTURE THERAPY; BRAIN-TUMOR; DELIVERY-SYSTEM; LIPOSOMES; CANCER; VEHICLES; TISSUE;

D O I：

10.7567/1882-0786/ab4a5d

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy to treat malignant tumors using a nuclear reaction of boron isotopes in tumor-localizing drug molecules. To evaluate the efficacy of boron drugs for BNCT, it is crucial to measure the distribution of boron drugs in cells. Here, we present the direct imaging of cellular uptake of boron cluster compound by stimulated Raman scattering microscopy. We demonstrate quantitative analysis of spatial distributions of disodium mercaptoundecahydrododecaborate (BSH)-cholesterol in HeLa cells. (C) 2019 The Japan Society of Applied Physics

引用

页数：4

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