Coordination of upregulated XBP-1 and downregulated c-myc during myeloma cell differentiation induced by 2-methoxyestradiol

被引：7
|
作者：
Zhou, Xia [1 ]
Jiang, Hua [1 ]
Hou, Jian [1 ]
机构：
[1] Second Mil Med Univ, Changzheng Hosp, Dept Hematol, Shanghai 200003, Peoples R China
来源：
LEUKEMIA RESEARCH | 2007年 / 31卷 / 09期
关键词：
2-methoxyestradiol (2ME2); differentiation; myeloma; XBP-1; c-myc; Blimp-1;
D O I：
10.1016/j.leukres.2006.11.023
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Our previous studies showed that 2-methoxyestradiol (2ME2) at low concentrations (0.1-0.5 mu mol/l) could induce differentiation of myeloma cells, and transcription factors Blimp-1 and XBP-1 repressed by Pax-5 were both upregulated. The present study was aimed at elucidating the molecular mechanism underlying 2ME2-induced myeloma cell differentiation. We demonstrated that cell differentiation required not only Blimp-1 to upregulate XBP-1 expression but also Blimp-1 to inhibit c-myc activity. These two signal transduction pathways worked dependently of each other and synergistically to promote the differentiation process of myeloma cells. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1259 / 1265
页数：7
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