The functional role of miRNAs in inflammatory pathways associated with intestinal epithelial tight junction barrier regulation in IBD

被引：0

作者：

Ochman, Blazej ^{[1
]}

Kula, Agnieszka ^{[2
]}

Swietochowska, Elzbieta ^{[1
]}

机构：

[1] Med Univ Silesia, Fac Med Sci Zabrze, Dept Med & Mol Biol, Zabrze, Poland

[2] Med Univ Silesia, Fac Med Sci Zabrze, Dept Oncol Surg, Katowice, Poland

来源：

POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2022年 / 76卷 / 01期

关键词：

inflammatory bowel disease; microRNA; tight junction protein; intestinal barrier; intestinal inflammation; tissue therapy; VITAMIN-D-RECEPTOR; NF-KAPPA-B; BOWEL-DISEASE; ULCERATIVE-COLITIS; SIGNALING PATHWAY; IMMUNE CELLS; TNF-ALPHA; TGF-BETA; MICRORNA; TARGETS;

D O I：

10.2478/ahem-2022-0038

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Inflammatory bowel disease - Crohn's disease and ulcerative colitis - is an immune-mediated chronic disorder with still not fully elucidated complex mechanisms of pathogenesis and pathophysiology. Intestinal epithelial barrier (IEB) dysregulation is one of the major underlying mechanisms of inflammatory process induction in IBD. Proper IEB integrity is maintained to a large extent by intercellular tight junctions, the function of which can be modified by many molecules, including miRNAs. MiRNAs belong to noncoding and non-messenger RNAs, which can modulate gene expression by binding predicted mRNAs. In this review, we summarize and discuss the potential role of miRNAs in the regulation of inflammatory signaling pathways affecting the function of the intestinal epithelial barrier in IBD, with particular emphasis on therapeutic potentials. The aim of the review is also to determine the further development directions of the studies on miRNA in the modulation of the intestinal epithelial barrier in IBD.

引用

页码：254 / 267

页数：14

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