Approaches for Analyzing the Roles of Mast Cells and Their Proteases In Vivo

被引:82
作者
Galli, Stephen J. [1 ,2 ]
Tsai, Mindy [1 ]
Marichal, Thomas [1 ,3 ,4 ]
Tchougounova, Elena [5 ]
Reber, Laurent L. [1 ]
Pejler, Gunnar [6 ,7 ]
机构
[1] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Microbiol & Immunol, Stanford, CA 94305 USA
[3] Univ Liege, GIGA Res, Liege, Belgium
[4] Univ Liege, Fac Vet Med, Liege, Belgium
[5] Uppsala Univ, Rudbeck Lab, Dept Immunol Genet & Pathol, Uppsala, Sweden
[6] Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden
[7] Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, Uppsala, Sweden
来源
ADVANCES IN IMMUNOLOGY, VOL 126 | 2015年 / 126卷
关键词
TUMOR-NECROSIS-FACTOR; C-KIT LIGAND; CONNECTIVE-TISSUE-TYPE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ABDOMINAL AORTIC-ANEURYSM; PHORBOL; 12-MYRISTATE; 13-ACETATE; DELAYED-TYPE HYPERSENSITIVITY; ALLERGIC AIRWAY INFLAMMATION; INDUCED PULMONARY-FIBROSIS; TYROSINE KINASE INHIBITOR;
D O I
10.1016/bs.ai.2014.11.002
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The roles of mast cells in health and disease remain incompletely understood. While the evidence that mast cells are critical effector cells in IgE-dependent anaphylaxis and other acute IgE-mediated allergic reactions seems unassailable, studies employing various mice deficient in mast cells or mast cell-associated proteases have yielded divergent conclusions about the roles of mast cells or their proteases in certain other immunological responses. Such "controversial" results call into question the relative utility of various older versus newer approaches to ascertain the roles of mast cells and mast cell proteases in vivo. This review discusses how both older and more recent mouse models have been used to investigate the functions of mast cells and their proteases in health and disease. We particularly focus on settings in which divergent conclusions about the importance of mast cells and their proteases have been supported by studies that employed different models of mast cell or mast cell protease deficiency. We think that two major conclusions can be drawn from such findings: (1) no matter which models of mast cell or mast cell protease deficiency one employs, the conclusions drawn from the experiments always should take into account the potential limitations of the models (particularly abnormalities affecting cell types other than mast cells) and (2) even when analyzing a biological response using a single model of mast cell or mast cell protease deficiency, details of experimental design are critical in efforts to define those conditions under which important contributions of mast cells or their proteases can be identified.
引用
收藏
页码:45 / 127
页数:83
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