HIV-1 elite controllers: Beware of super-infections

被引：24
|
作者：
Clerc, Olivier [1 ,2 ]
Colombo, Sara [2 ,3 ]
Yerly, Sabine [4 ,5 ]
Telenti, Amalio [2 ,3 ]
Cavassini, Matthias [1 ,2 ]
机构：
[1] CHU Vaudois, Infect Dis Serv, CH-1011 Lausanne, Switzerland
[2] Univ Lausanne, CH-1011 Lausanne, Switzerland
[3] CHU Vaudois, Inst Microbiol, CH-1011 Lausanne, Switzerland
[4] Univ Hosp Geneva, Virol Lab, CH-1211 Geneva, Switzerland
[5] Univ Hosp Geneva, AIDS Ctr, CH-1211 Geneva, Switzerland
来源：
JOURNAL OF CLINICAL VIROLOGY | 2010年 / 47卷 / 04期
关键词：
HIV-1; super-infection; Elite controller; Virological progression; IMMUNODEFICIENCY-VIRUS TYPE-1; SEXUAL RISK-TAKING; LONG-TERM; VIRAL LOAD; SUPERINFECTION; PROGRESSION; THERAPY; PATIENT; ABSENCE; DISEASE;
D O I：
10.1016/j.jcv.2010.01.013
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Super- and co-infection with HIV-1 are generally associated with accelerated disease progression. We report on the outcome of super-infection in two HIV-1 infected individuals previously known as elite controllers. Both presented an acute retroviral syndrome following super-infection and showed an immuno-virological progression thereafter. Host genotyping failed to reveal any of the currently recognized protective factors associated with slow disease progression. This report indicates that elite controllers should be informed of the risk of super-infection, and illustrates the complexity of mounting broad anti-HIV immunity. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：376 / 378
页数：3
相关论文
共 50 条
  • [41] ECHINOCOCCUS-MULTILOCULARIS - SUPER-INFECTIONS IN EXPERIMENTALLY INFECTED MICE
    HINZ, E
    TROPENMEDIZIN UND PARASITOLOGIE, 1979, 30 (03): : 387 - 390
  • [42] Genetic analyses suggest functional differences in the nature of persistent viraemia between HIV-1 elite controllers and therapy exposed controllers
    Mens, H.
    Kearney, M.
    Wiegand, A.
    Schonning, K.
    Gerstoft, J.
    Obel, N.
    Maldarelli, F.
    Mellors, J. W.
    Benfield, T.
    Coffin, J. M.
    ANTIVIRAL THERAPY, 2010, 15 : A171 - A171
  • [43] INTERFERENCE IN THE ESTABLISHMENT OF SUPER-INFECTIONS WITH TRYPANOSOMA-CONGOLENSE IN CATTLE
    MORRISON, WI
    WELLS, PW
    MOLOO, SK
    PARIS, J
    MURRAY, M
    JOURNAL OF PARASITOLOGY, 1982, 68 (05) : 755 - 764
  • [44] A Distinct Treg Transcriptome Signature in HIV-1 Elite Controllers Might Contribute to Improved Disease Outcome
    Dahlke, Christine
    Angin, Mathieu
    Mueller, Christian
    Sharma, Siddharta
    Bhasin, Manoj K.
    Zhuang, Yan
    Addo, Marylyn M.
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2014, 30 : A180 - A180
  • [45] Anti-APOBEC3G Activity of HIV-1 Vif Protein Is Attenuated in Elite Controllers
    Kikuchi, Tadashi
    Iwabu, Yukie
    Tada, Takuya
    Kawana-Tachikawa, Ai
    Koga, Michiko
    Hosoya, Noriaki
    Nomura, Shigeru
    Brumme, Zabrina L.
    Jessen, Heiko
    Pereyra, Florencia
    Trocha, Alicja
    Walker, Bruce D.
    Iwamoto, Aikichi
    Tokunaga, Kenzo
    Miura, Toshiyuki
    JOURNAL OF VIROLOGY, 2015, 89 (09) : 4992 - 5001
  • [46] Differential Gag-Specific Polyfunctional T Cell Maturation Patterns in HIV-1 Elite Controllers
    Ferrando-Martinez, Sara
    Casazza, Joseph P.
    Leal, Manuel
    Machmach, Kawthar
    Angeles Munoz-Fernandez, Ma
    Viciana, Pompeyo
    Koup, Richard A.
    Ruiz-Mateos, Ezequiel
    JOURNAL OF VIROLOGY, 2012, 86 (07) : 3667 - 3674
  • [47] REACTION OF INTERMEDIATE HOST TO SUPER-INFECTIONS WITH ECHINOCOCCUS-MULTILOCULARIS
    HINZ, E
    TROPENMEDIZIN UND PARASITOLOGIE, 1979, 30 (02): : 143 - 144
  • [48] "HIV-1 controllers" - what's their secret?
    Madhavi, V
    Wines, B.
    Emery, S.
    Amin, J.
    Kelleher, A.
    Hogarth, M.
    Stratov, I
    Kent, S.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 74 - 74
  • [49] Increased biomarkers of cardiovascular risk in HIV-1 viremic controllers and low persistent inflammation in elite controllers and art-suppressed individuals
    Caetano, Diogo Gama
    Ribeiro-Alves, Marcelo
    Hottz, Eugenio Damaceno
    Vilela, Larissa Melo
    Cardoso, Sandra Wagner
    Hoagland, Brenda
    Grinsztejn, Beatriz
    Veloso, Valdilea Goncalves
    Morgado, Mariza Goncalves
    Bozza, Patricia Torres
    Guimaraes, Monick Lindenmeyer
    Cortes, Fernanda Heloise
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [50] Increased biomarkers of cardiovascular risk in HIV-1 viremic controllers and low persistent inflammation in elite controllers and art-suppressed individuals
    Diogo Gama Caetano
    Marcelo Ribeiro-Alves
    Eugênio Damaceno Hottz
    Larissa Melo Vilela
    Sandra Wagner Cardoso
    Brenda Hoagland
    Beatriz Grinsztejn
    Valdilea Gonçalves Veloso
    Mariza Gonçalves Morgado
    Patrícia Torres Bozza
    Monick Lindenmeyer Guimarães
    Fernanda Heloise Côrtes
    Scientific Reports, 12
12345