HIV-1 elite controllers: Beware of super-infections

被引：24
|
作者：
Clerc, Olivier [1 ,2 ]
Colombo, Sara [2 ,3 ]
Yerly, Sabine [4 ,5 ]
Telenti, Amalio [2 ,3 ]
Cavassini, Matthias [1 ,2 ]
机构：
[1] CHU Vaudois, Infect Dis Serv, CH-1011 Lausanne, Switzerland
[2] Univ Lausanne, CH-1011 Lausanne, Switzerland
[3] CHU Vaudois, Inst Microbiol, CH-1011 Lausanne, Switzerland
[4] Univ Hosp Geneva, Virol Lab, CH-1211 Geneva, Switzerland
[5] Univ Hosp Geneva, AIDS Ctr, CH-1211 Geneva, Switzerland
来源：
JOURNAL OF CLINICAL VIROLOGY | 2010年 / 47卷 / 04期
关键词：
HIV-1; super-infection; Elite controller; Virological progression; IMMUNODEFICIENCY-VIRUS TYPE-1; SEXUAL RISK-TAKING; LONG-TERM; VIRAL LOAD; SUPERINFECTION; PROGRESSION; THERAPY; PATIENT; ABSENCE; DISEASE;
D O I：
10.1016/j.jcv.2010.01.013
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Super- and co-infection with HIV-1 are generally associated with accelerated disease progression. We report on the outcome of super-infection in two HIV-1 infected individuals previously known as elite controllers. Both presented an acute retroviral syndrome following super-infection and showed an immuno-virological progression thereafter. Host genotyping failed to reveal any of the currently recognized protective factors associated with slow disease progression. This report indicates that elite controllers should be informed of the risk of super-infection, and illustrates the complexity of mounting broad anti-HIV immunity. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：376 / 378
页数：3
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