Early prediction of response to cetuximab and radiotherapy by FDG-PET/CT for the treatment of a locoregionally advanced squamous cell carcinoma of the hypopharynx

被引：2
作者：
Grybauskas, Mindaugas [1 ]
Daisne, Jean-Francois [2 ]
Aleknavicius, Eduardas [3 ,4 ]
Burneckis, Arvydas [1 ]
机构：
[1] Natl Canc Inst, Dept Radiat Oncol, LT-08660 Vilnius, Lithuania
[2] Clin & Matern St Elisabeth, Dept Radiat Oncol, Namur, Belgium
[3] Natl Canc Inst, Radiotherapy & Drug Therapy Ctr, LT-08660 Vilnius, Lithuania
[4] Vilnius Univ, Fac Med, Vilnius, Lithuania
来源：
MEDICINA-LITHUANIA | 2014年 / 50卷 / 04期
关键词：
Cetuximab; Head and neck cancer; Predictive marker; FDG-PET/CT; Radiotherapy; POSITRON-EMISSION-TOMOGRAPHY; DOWN-REGULATION; CANCER-CELLS; HYPOXIA; EGFR; METABOLISM; THERAPY;
D O I：
10.1016/j.medici.2014.09.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cetuximab (CTX) is used for the concurrent treatment with radiotherapy (RT) in squamous cell carcinoma of head and neck (HNSCC). There are no reliable clinical predictive markers of effectiveness of CTX at yet. We describe the clinical case of patient who received a CTX/RT to cure locoregionally advanced hypopharyngeal SCC. 2-Deoxy-2[F-18]fluoro-D-glucose positron emission tomography and computed tomography ((18)FDG-PET/CT) was performed before the treatment and repeated 10 days after CTX induction dose. A repeated (18)FDG-PET/CT scan showed dramatic decrease of metabolic parameters. Patient had a complete response after treatment and is still alive and cured after 5 years. (C) 2014 Lithuanian University of Health Sciences. Production and hosting by Elsevier Urban & Partner Sp. z o.o. All rights reserved.
引用
收藏
页码：245 / 248
页数：4
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