Engineering Chimeric Antigen Receptors

被引：16

作者：

Kulemzin, S. V. ^{[1
]}

Kuznetsova, V. V. ^{[1
]}

Mamonkin, M. ^{[3
,4
]}

Taranin, A. V. ^{[1
,2
]}

Gorchakov, A. A. ^{[1
,2
]}

机构：

[1] SB RAS, Inst Mol & Cellular Biol, Lavrentiev Ave 8-2, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Pirogova Str 2, Novosibirsk 630090, Russia

[3] Texas Childrens Hosp, Baylor Coll Med, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[4] Houston Methodist Hosp, Houston, TX USA

来源：

ACTA NATURAE | 2017年 / 9卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

adoptive immunotherapy; cancer; chimeric antigen receptor; T cells; MODIFIED T-CELLS; SINGLE-CHAIN FV; FC-GAMMA RIIIA; ADOPTIVE IMMUNOTHERAPY; CD28; COSTIMULATION; ANTITUMOR-ACTIVITY; ENHANCED SURVIVAL; SIGNALING DOMAINS; IMMUNE RECEPTORS; REPEAT PROTEINS;

D O I：

10.32607/20758251-2017-9-1-6-14

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chimeric antigen receptors (CARs) are recombinant protein molecules that redirect cytotoxic lymphocytes toward malignant and other target cells. The high feasibility of manufacturing CAR-modified lymphocytes for the therapy of cancer has spurred the development and optimization of new CAR T cells directed against a broad range of target antigens. In this review, we describe the main structural and functional elements constituting a CAR, discuss the roles of these elements in modulating the anti-tumor activity of CAR T cells, and highlight alternative approaches to CAR engineering.

引用

页码：6 / 14

页数：9

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