Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity

被引：499

作者：

Arias, Lais Salomao ^{[1
]}

Pessan, Juliano Pelim ^{[1
]}

Miranda Vieira, Ana Paula ^{[1
]}

Toito de Lima, Taynara Maria ^{[2
]}

Botazzo Delbem, Alberto Carlos ^{[1
]}

Monteiro, Douglas Roberto ^{[2
]}

机构：

[1] Sao Paulo State Univ Unesp, Sch Dent, Dept Pediat Dent & Publ Hlth, BR-16015050 Aracatuba, SP, Brazil

[2] Univ Western Sao Paulo UNOESTE, Grad Program Dent GPD Masters Degree, BR-19050920 Presidente Prudente, SP, Brazil

来源：

ANTIBIOTICS-BASEL | 2018年 / 7卷 / 02期

关键词：

biotechnology; drug delivery; iron oxide nanoparticles; magnetic nanoparticles; IN-VITRO EVALUATION; MODIFIED MAGNETIC NANOPARTICLES; COATED FE3O4 NANOPARTICLES; TARGETED DELIVERY; THERMAL-DECOMPOSITION; CANCER-THERAPY; SERUM-ALBUMIN; COMPOSITE NANOPARTICLES; ANTIBACTERIAL ACTIVITY; CELLULAR UPTAKE;

D O I：

10.3390/antibiotics7020046

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Medical applications and biotechnological advances, including magnetic resonance imaging, cell separation and detection, tissue repair, magnetic hyperthermia and drug delivery, have strongly benefited from employing iron oxide nanoparticles (IONPs) due to their remarkable properties, such as superparamagnetism, size and possibility of receiving a biocompatible coating. Ongoing research efforts focus on reducing drug concentration, toxicity, and other side effects, while increasing efficacy of IONPs-based treatments. This review highlights the methods of synthesis and presents the most recent reports in the literature regarding advances in drug delivery using IONPs-based systems, as well as their antimicrobial activity against different microorganisms. Furthermore, the toxicity of IONPs alone and constituting nanosystems is also addressed.

引用

页数：32

共 259 条

[41] Hierarchical self-assembly of magnetic nanoclusters for theranostics: Tunable size, enhanced magnetic resonance imagability, and controlled and targeted drug delivery [J].