Synthesis of mesoporous silica nanoparticles and nanorods: Application to doxorubicin delivery

被引：36

作者：

Rahmani, Saher ^{[1
,2
]}

Durand, Jean-Olivier ^{[1
]}

Charnay, Clarence ^{[1
]}

Lichon, Laure ^{[3
]}

Ferid, Mokhtar ^{[2
]}

Garcia, Marcel ^{[3
]}

Gary-Bobo, Magali ^{[3
]}

机构：

[1] Inst Charles Gerhardt Montpellier, Equipe Ingn Mol & Nanoobjets, UMR 5253, CC 1701, Pl Eugene Bataillon, F-34095 Montpellier 05, France

[2] Ctr Natl Rech Sci Mat, Lab Physicochim Mat Mineraux & Leurs Applicat, BP 95, Hammam Lif 2050, Tunisia

[3] Inst Biomol Max Mousseron, UMR 5247, Ave Charles Flahault, F-34093 Montpellier 05, France

来源：

SOLID STATE SCIENCES | 2017年 / 68卷

关键词：

CONTROLLED DRUG-DELIVERY; CONTROLLED-RELEASE; THERANOSTIC APPLICATIONS; PORE-SIZE; CANCER; BIOCOMPATIBILITY; RESISTANCE; MORPHOLOGY; CARRIERS; SYSTEM;

D O I：

10.1016/j.solidstatesciences.2017.04.003

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis and application of mesoporous silica nanoparticles (MSN) and mesoporous silica nanorods (MSNR) for drug delivery were described. MSN or MSNR were obtained by adjusting the amount of added cosolvent to the sol-gel solution. Therefore, the addition of ethanol (EtOH) has contributed to the control of the particle shape and to the structure of the mesoporosity. MSN and MSNR particles were then loaded with doxorubicin and incubated with MCF-7 breast cancer cells. MSN and MSNR particles were efficient in killing cancer cells but their behavior in drug delivery was altered on account of the difference in their morphology. MSN showed a burst release of doxorubicin in cells whereas MSNR showed a sustained delivery of the anti-cancer drug. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：25 / 31

页数：7

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[1] Multifunctional Mesoporous Silica Nanoparticles as a Universal Platform for Drug Delivery [J].