African swine fever virus replication events and cell nucleus: New insights and perspectives

被引：44

作者：

Simoes, Margarida ^{[1
,2
]}

Freitas, Ferdinando B. ^{[1
]}

Leitao, Alexandre ^{[1
]}

Martins, Carlos ^{[1
]}

Ferreira, Fernando ^{[1
]}

机构：

[1] Univ Lisbon, Fac Med Vet, CIISA, Ave Univ Tecn, P-1300477 Lisbon, Portugal

[2] INIAV, Lab Virol, P-2780157 Oeiras, Portugal

来源：

VIRUS RESEARCH | 2019年 / 270卷

关键词：

ASFV; Subnuclear domains; DDR; Epigenetic signatures; replication enzymes; DNA-DAMAGE RESPONSE; UBIQUITIN-CONJUGATING ENZYME; HISTONE DEACETYLASE; HUMAN-CYTOMEGALOVIRUS; IN-VITRO; BINDING-PROTEIN; CAJAL BODIES; EPIGENETIC REGULATION; TOPOISOMERASE-II; TUMOR-VIRUSES;

D O I：

10.1016/j.virusres.2019.197667

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

African swine fever (ASF) is currently matter for major concerns in global swine industry as it is highly contagious and causes acute fatal haemorrhagic fever in domestic pigs and wild boar. The absence of effective vaccines and treatments pushes ASF control to relay on strict sanitary and stamping out measures with costly socio-economic impacts. The current epidemic scenario of fast spreading throughout Asiatic countries impels further studies on prevention and combat strategies against ASF. Herein we review knowledge on African Swine Fever Virus (ASFV) interactions with the host cell nucleus and on the functional properties of different viral DNA-replication related proteins. This entails, the confirmation of an intranuclear viral DNA replication phase, the characterization of cellular DNA damage responses (DDR), the subnuclear compartments disruption due to viral modulation, and the unravelling of the biological role of several viral proteins (A104R, 1215 L, P1192R, QP509 L and Q706 L), so to contribute to underpin rational strategies for vaccine candidates development.

引用

页数：10

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