Structure-activity relationships of some complex I inhibitors

被引：103

作者：

Miyoshi, H ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Sakyo Ku, Kyoto 60601, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 1998年 / 1364卷 / 02期

关键词：

complex I; mitochondrion; respiratory inhibitor; structure-activity relationship;

D O I：

10.1016/S0005-2728(98)00030-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A wide variety of complex I inhibitors act at or close to the ubiquinone reduction site. Identification of the structural factors required for exhibiting inhibitory actions on the basis of structure-activity relationships is useful to elucidate the manner in which inhibitors interact with the enzyme. This review summarizes studies on the structure-activity relationship of rotenoids, piericidins, capsaicins, pyridinium-type inhibitors and modern synthetic agrochemicals acting at mitochondrial complex I. (C) 1998 Elsevier Science B.V.

引用

页码：236 / 244

页数：9

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