Spatial Map of Human T Cell Compartmentalization and Maintenance over Decades of Life

被引：429

作者：

Thome, Joseph J. C. ^{[1
,3
]}

Yudanin, Naomi ^{[1
,3
]}

Ohmura, Yoshiaki ^{[2
]}

Kubota, Masaru ^{[2
]}

Grinshpun, Boris ^{[4
,5
]}

Sathaliyawala, Taheri ^{[1
]}

Kato, Tomoaki ^{[2
]}

Lerner, Harvey ^{[6
]}

Shen, Yufeng ^{[4
,5
]}

Farber, Donna L. ^{[1
,2
,3
]}

机构：

[1] Columbia Univ, Columbia Ctr Translat Immunol, Med Ctr, New York, NY 10032 USA

[2] Columbia Univ, Med Ctr, Dept Surg, New York, NY 10032 USA

[3] Columbia Univ, Med Ctr, Dept Microbiol & Immunol, New York, NY 10032 USA

[4] Columbia Univ, Dept Syst Biol & Biomed Informat, New York, NY 10032 USA

[5] Columbia Univ, JP Sulzberger Columbia Genome Ctr, New York, NY 10032 USA

[6] New York Organ Donor Network, New York, NY 10001 USA

来源：

CELL | 2014年 / 159卷 / 04期

关键词：

EFFECTOR-MEMORY; RHEUMATOID-ARTHRITIS; LYMPHOID ORGANS; DOWN-REGULATION; EXPRESSION; RESIDENT; CD4(+); SUBSETS; CCR7; DIFFERENTIATION;

D O I：

10.1016/j.cell.2014.10.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mechanisms for human memory T cell differentiation and maintenance have largely been inferred from studies of peripheral blood, though the majority of T cells are found in lymphoid and mucosal sites. We present here a multidimensional, quantitative analysis of human T cell compartmentalization and maintenance over six decades of life in blood, lymphoid, and mucosal tissues obtained from 56 individual organ donors. Our results reveal that the distribution and tissue residence of naive, central, and effector memory, and terminal effector subsets is contingent on both their differentiation state and tissue localization. Moreover, T cell homeostasis driven by cytokine or TCR-mediated signals is different in CD4+ or CD8+ T cell lineages, varies with their differentiation stage and tissue localization, and cannot be inferred from blood. Our data provide an unprecedented spatial and temporal map of human T cell compartmentalization and maintenance, supporting distinct pathways for human T cell fate determination and homeostasis.

引用

页码：814 / 828

页数：15

共 42 条

[1] The precursors of memory: models and controversies [J].