First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism

被引：56

作者：

Chung, Brian T. ^{[1
,2
]}

Chen, Hsin-Yu ^{[1
]}

Gordon, Jeremy ^{[1
]}

Mammoli, Daniele ^{[1
]}

Sriram, Renuka ^{[1
]}

Autry, Adam W. ^{[1
]}

Le Page, Lydia M. ^{[1
,3
]}

Chaumeil, Myriam M. ^{[1
,3
]}

Shin, Peter ^{[1
]}

Slater, James ^{[1
]}

Tan, Chou T. ^{[4
]}

Suszczynski, Chris ^{[4
]}

Chang, Susan ^{[5
]}

Li, Yan ^{[1
]}

Bok, Robert A. ^{[1
]}

Ronen, Sabrina M. ^{[1
]}

Larson, Peder E. Z. ^{[1
]}

Kurhanewicz, John ^{[1
]}

Vigneron, Daniel B. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, 1700 Fourth St,Byers Hall Suite 102, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, UCSF UC Berkeley Grad Program Bioengn, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Phys Therapy & Rehabil Sci, San Francisco, CA 94158 USA

[4] Merck KGaA, ISOTEC Stable Isotope Div, MilliporeSigma, Miamisburg, OH 45342 USA

[5] Univ Calif San Francisco, Dept Med, San Francisco, CA 94158 USA

来源：

JOURNAL OF MAGNETIC RESONANCE | 2019年 / 309卷

关键词：

Hyperpolarized C13; Metabolic imaging; Brain metabolism; C-13; PYRUVATE; CYCLE;

D O I：

10.1016/j.jmr.2019.106617

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We developed methods for the preparation of hyperpolarized (HP) sterile [2-C-13]pyruvate to test its feasibility in first-ever human NMR studies following FDA-IND & IRB approval. Spectral results using this MR stable-isotope imaging approach demonstrated the feasibility of investigating human cerebral energy metabolism by measuring the dynamic conversion of HP [2-C-13]pyruvate to [2-C-13]lactate and [5-C-13]glutamate in the brain of four healthy volunteers. Metabolite kinetics, signal-to-noise (SNR) and area-undercurve (AUC) ratios, and calculated [2-C-13]pyruvate to [2-C-13]lactate conversion rates (k(PL)) were measured and showed similar but not identical inter-subject values. The k(PL) measurements were equivalent with prior human HP [1-C-13]pyruvate measurements. (C) 2019 Elsevier Inc. All rights reserved.

引用

页数：7

共 50 条

[31] Lactate saturation limits bicarbonate detection in hyperpolarized 13C-pyruvate MRI of the brain [J].

Bogh, Nikolaj ;

Grist, James T. ;

Rasmussen, Camilla W. ;

Bertelsen, Lotte B. ;

Hansen, Esben S. S. ;

Blicher, Jakob U. ;

Tyler, Damian J. ;

Laustsen, Christoffer .

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[32] Rapid Multislice Imaging of Hyperpolarized 13C Pyruvate and Bicarbonate in the Heart [J].

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Chen, Albert P. ;

Ghugre, Nilesh R. ;

Ramanan, Venkat ;

Lam, Wilfred W. ;

Connelly, Kim A. ;

Wright, Graham A. ;

Cunningham, Charles H. .

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[33] Longitudinal assessment of mitochondrial dysfunction in acute traumatic brain injury using hyperpolarized [1-13C]pyruvate [J].

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Ingle, Laura ;

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Barshikar, Surendra ;

Pinho, Marco da Cunha ;

Plautz, Erik J. ;

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Spielman, Daniel ;

Yen, Yi-Fen ;

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[35] Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice [J].

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Albers, Mark J. ;

Zhang, Vickie ;

Tropp, Jim ;

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Vigneron, Daniel B. ;

Kurhanewicz, John ;

Hurd, Ralph E. ;

Nelson, Sarah J. .

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[36] Metabolism of hyperpolarized [1-13C]pyruvate in the isolated perfused rat lung - an ischemia study [J].

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Kadlecek, S. ;

Rizi, R. R. .

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[37] Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-13C]pyruvate MRI [J].

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Bertelsen, Lotte B. ;

Blicher, Jakob U. .

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[38] Investigating the origin of the 13C lactate signal in the anesthetized healthy rat brain in vivo after hyperpolarized [1-13C]pyruvate injection [J].

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Yen, Yi-Fen ;

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[39] Metabolic Imaging of Hyperpolarized [1-13C]Pyruvate in a Ferret Model of Traumatic Brain Injury [J].

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Hrdlick, Amanda L. ;

Piskoun, Boris ;

Rogers, Joshua C. ;

Jhajharia, Aditya ;

Zhu, Minjie ;

Proctor, Julie L. ;

Leiste, Ulrich H. ;

Fourney, William L. ;

Cantu, Jody C. ;

Fiskum, Gary ;

Goodfellow, Molly J. .

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[40] Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy [J].

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