First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism

被引：55

作者：

Chung, Brian T. ^{[1
,2
]}

Chen, Hsin-Yu ^{[1
]}

Gordon, Jeremy ^{[1
]}

Mammoli, Daniele ^{[1
]}

Sriram, Renuka ^{[1
]}

Autry, Adam W. ^{[1
]}

Le Page, Lydia M. ^{[1
,3
]}

Chaumeil, Myriam M. ^{[1
,3
]}

Shin, Peter ^{[1
]}

Slater, James ^{[1
]}

Tan, Chou T. ^{[4
]}

Suszczynski, Chris ^{[4
]}

Chang, Susan ^{[5
]}

Li, Yan ^{[1
]}

Bok, Robert A. ^{[1
]}

Ronen, Sabrina M. ^{[1
]}

Larson, Peder E. Z. ^{[1
]}

Kurhanewicz, John ^{[1
]}

Vigneron, Daniel B. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, 1700 Fourth St,Byers Hall Suite 102, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, UCSF UC Berkeley Grad Program Bioengn, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Phys Therapy & Rehabil Sci, San Francisco, CA 94158 USA

[4] Merck KGaA, ISOTEC Stable Isotope Div, MilliporeSigma, Miamisburg, OH 45342 USA

[5] Univ Calif San Francisco, Dept Med, San Francisco, CA 94158 USA

来源：

JOURNAL OF MAGNETIC RESONANCE | 2019年 / 309卷

关键词：

Hyperpolarized C13; Metabolic imaging; Brain metabolism; C-13; PYRUVATE; CYCLE;

D O I：

10.1016/j.jmr.2019.106617

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We developed methods for the preparation of hyperpolarized (HP) sterile [2-C-13]pyruvate to test its feasibility in first-ever human NMR studies following FDA-IND & IRB approval. Spectral results using this MR stable-isotope imaging approach demonstrated the feasibility of investigating human cerebral energy metabolism by measuring the dynamic conversion of HP [2-C-13]pyruvate to [2-C-13]lactate and [5-C-13]glutamate in the brain of four healthy volunteers. Metabolite kinetics, signal-to-noise (SNR) and area-undercurve (AUC) ratios, and calculated [2-C-13]pyruvate to [2-C-13]lactate conversion rates (k(PL)) were measured and showed similar but not identical inter-subject values. The k(PL) measurements were equivalent with prior human HP [1-C-13]pyruvate measurements. (C) 2019 Elsevier Inc. All rights reserved.

引用

页数：7

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