Nonstructured Treatment Interruptions Are Associated With Higher Human Immunodeficiency Virus Reservoir Size Measured by Intact Proviral DNA Assay in People Who Inject Drugs

被引：7

作者：

Kirk, Gregory D. ^{[1
,2
]}

Astemborski, Jacqueline ^{[1
]}

Mehta, Shruti H. ^{[1
]}

Ritter, Kristen D. ^{[3
]}

Laird, Gregory M. ^{[3
]}

Bordi, Rebeka ^{[4
]}

Sekaly, Rafick ^{[4
]}

Siliciano, Janet D. ^{[2
]}

Siliciano, Robert F. ^{[2
,5
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[2] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21205 USA

[3] Accelevir Diagnost, Baltimore, MD USA

[4] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

[5] Howard Hughes Med Inst, Baltimore, MD USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 223卷 / 11期

关键词：

HIV-1 latent reservoir; HIV-1 viral suppression; people who inject drugs; PWID; antiretroviral therapy; ART; nonstructured treatment interruption; NTI; CD4(+) T-CELLS; LATENT RESERVOIR; HIV-1; PROVIRUSES; IDENTIFICATION; SUPPRESSION; STABILITY; INFECTION; PROVIDES; PROTEIN; CARE;

D O I：

10.1093/infdis/jiaa634

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The latent reservoir for human immunodeficiency virus type 1 (HIV-1) in CD4(+)T cells is a major barrier to cure. HIV-1-infected persons who inject drugs (PWID) often struggle to maintain suppression of viremia and experience nonstructured treatment interruptions (NTIs). The effects of injecting drugs or NTIs on the reservoir are unclear. Using the intact proviral DNA assay, we found no apparent effect of heroin or cocaine use on reservoir size. However, we found significantly larger reservoirs in those with frequent NTIs or a shorter interval from last detectable HIV RNA measurement. These results have important implications for inclusion of PWID in HIV-1 cure studies.

引用

页码：1905 / 1913

页数：9

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