Body mass index and survival of patients with lymphoma

被引：8

作者：

Chihara, Dai ^{[1
,2
]}

Larson, Melissa C. ^{[3
]}

Robinson, Dennis P. ^{[3
]}

Thompson, Carrie A. ^{[4
]}

Maurer, Matthew J. ^{[3
]}

Casulo, Carla ^{[5
]}

Pophali, Priyanka ^{[6
]}

Link, Brian K. ^{[7
]}

Habermann, Thomas M. ^{[4
]}

Feldman, Andrew L. ^{[8
]}

Flowers, Christopher R. ^{[1
]}

Cerhan, James R. ^{[3
]}

Morton, Lindsay M. ^{[9
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA

[2] NCI, Med Oncol Serv, NIH, Bethesda, MD 20892 USA

[3] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[4] Mayo Clin, Div Hematol, Dept Internal Med, Rochester, MN USA

[5] Univ Rochester, Med Ctr, Dept Med, James P Wilmot Canc Inst, Rochester, NY 14642 USA

[6] Univ Wisconsin, Dept Med, Div Hematol Oncol & Palliat Care, Madison, WI USA

[7] Univ Iowa, Dept Internal Med, Div Hematol Oncol & Blood & Marrow Transplantat, Carver Coll Med, Iowa City, IA 52242 USA

[8] Mayo Clin, Div Hematopathol, Dept Lab Med & Pathol, Rochester, MN USA

[9] NCI, Dept Hlth & Human Serv, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet,NIH, Bethesda, MD 20892 USA

来源：

LEUKEMIA & LYMPHOMA | 2021年 / 62卷 / 11期

关键词：

Diffuse large B-cell lymphoma; follicular lymphoma; CLL; SLL; body mass index; survival; NON-HODGKIN-LYMPHOMA; ELDERLY-PATIENTS; SERUM-LEVELS; PROGNOSIS; DISEASE; IMPACT; LIFE;

D O I：

10.1080/10428194.2021.1929956

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The impact of body mass index (BMI) on survival in lymphoma remains controversial. We leveraged a prospective cohort of lymphoma patients enrolled to SPORE Molecular Epidemiology Resource between 2002 and 2015 to assess the association of BMI before diagnosis, BMI at diagnosis, and BMI change over time with lymphoma-specific survival (LSS). A total of 4009 lymphoma patients (670 diffuse large B-cell lymphoma (DLBCL), 689 follicular lymphoma (FL), 1018 chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and 1632 other subtypes) were included. Significantly shorter LSS after diagnosis was observed for FL patients who were obese before diagnosis (HR: 3.02, 95%CI: 1.43-6.41, p=.004) and for those with a >= 5% increase in BMI from diagnosis to 3-year follow-up (HR: 3.53, 95%CI: 1.22-10.2, p=.020). In contrast, obesity prior to or at the time of diagnosis was not associated with LSS in DLBCL and CLL/SLL. The impact of weight control after diagnosis in FL patient warrants investigation.

引用

页码：2671 / 2678

页数：8

共 27 条

[1] Elevated pretreatment serum levels of interferon-inducible protein-10 (CXCL10) predict disease relapse and prognosis in diffuse large B-cell lymphoma patients [J].

Ansell, Stephen M. ;

Maurer, Matthew J. ;

Ziesmer, Steven C. ;

Slager, Susan L. ;

Habermann, Thomas M. ;

Link, Brian K. ;

Witzig, Thomas E. ;

Macon, William R. ;

Dogan, Ahmet ;

Cerhan, James R. ;

Novak, Anne J. .

AMERICAN JOURNAL OF HEMATOLOGY, 2012, 87 (09) :865-869

[2] Physical activity, obesity and survival in diffuse large B-cell and follicular lymphoma cases [J].

Boyle, Terry ;

Connors, Joseph M. ;

Gascoyne, Randy D. ;

Berry, Brian R. ;

Sehn, Laurie H. ;

Bashash, Morteza ;

Spinelli, John J. .

BRITISH JOURNAL OF HAEMATOLOGY, 2017, 178 (03) :442-447

[3] Increased Body Mass Index Is Associated With Improved Survival in United States Veterans With Diffuse Large B-Cell Lymphoma [J].

Carson, Kenneth R. ;

Bartlett, Nancy L. ;

McDonald, Jay R. ;

Luo, Suhong ;

Zeringue, Angelique ;

Liu, Jingxia ;

Fu, Qiang ;

Chang, Su-Hsin ;

Colditz, Graham A. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (26) :3217-3222

[4] Cohort Profile: The Lymphoma Specialized Program of Research Excellence (SPORE) Molecular Epidemiology Resource (MER) Cohort Study [J].

Cerhan, James R. ;

Link, Brian K. ;

Habermann, Thomas M. ;

Maurer, Matthew J. ;

Feldman, Andrew L. ;

Syrbu, Sergei I. ;

Thompson, Carrie A. ;

Farooq, Umar ;

Novak, Anne J. ;

Slager, Susan L. ;

Allmer, Cristine ;

Lunde, Julianne J. ;

Macon, William R. ;

Inwards, David J. ;

Johnston, Patrick B. ;

Micallef, Ivana N. M. ;

Nowakowski, Grzegorz S. ;

Ansell, Stephen M. ;

Kay, Neil E. ;

Weiner, George J. ;

Witzig, Thomas E. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2017, 46 (06) :1753-+

[5] Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents [J].

Di Angelantonio, Emanuele ;

Bhupathiraju, Shilpa N. ;

Wormser, David ;

Gao, Pei ;

Kaptoge, Stephen ;

de Gonzalez, Amy Berrington ;

Cairns, Benjamin J. ;

Huxley, Rachel ;

Jackson, Chandra L. ;

Joshy, Grace ;

Lewington, Sarah ;

Manson, JoAnn E. ;

Murphy, Neil ;

Patel, Alpa V. ;

Samet, Jonathan M. ;

Woodward, Mark ;

Zheng, Wei ;

Zhou, Maigen ;

Bansal, Narinder ;

Barricarte, Aurelio ;

Carter, Brian ;

Cerhan, James R. ;

Collins, Rory ;

Smith, George Davey ;

Fang, Xianghua ;

Franco, Oscar H. ;

Green, Jane ;

Halsey, Jim ;

Hildebrand, Janet S. ;

Jung, Keum Ji ;

Korda, Rosemary J. ;

McLerran, Dale F. ;

Moore, Steven C. ;

O'Keeff, Linda M. ;

Paige, Ellie ;

Ramond, Anna ;

Reeves, Gillian K. ;

Rolland, Betsy ;

Sacerdote, Carlotta ;

Sattar, Naveed ;

Sofianopoulou, Eleni ;

Stevens, June ;

Thun, Michael ;

Ueshima, Hirotsugu ;

Yang, Ling ;

Yun, Young Duk ;

Willeit, Peter ;

Banks, Emily ;

Beral, Valerie ;

Chen, Zhengming .

LANCET, 2016, 388 (10046) :776-786

[6]

Ezzati M, 2017, LANCET, V390, P2627, DOI [10.1016/S0140-6736(17)32129-3, 10.1016/s0140-6736(17)32129-3]

[7] Impact of doxorubicin dose capping on the outcome of DLBCL patients with elevated body surface area [J].

Gay, Caroline ;

Delarue, Richard ;

Milpied, Noel ;

Oberic, Lucie ;

Coiffier, Bertrand ;

Boussetta, Sami ;

Haioun, Corinne ;

Tilly, Herve ;

Salles, Gilles ;

Lamy, Thierry ;

Lester, Marie-Antoinette ;

Houot, Roch .

BLOOD, 2017, 129 (20) :2811-2813

[8] Smoking, Alcohol Use, Obesity, and Overall Survival From Non-Hodgkin Lymphoma [J].

Geyer, Susan M. ;

Morton, Lindsay M. ;

Habermann, Thomas M. ;

Allmer, Cristine ;

Davis, Scott ;

Cozen, Wendy ;

Severson, Richard K. ;

Lynch, Charles F. ;

Wang, Sophia S. ;

Maurer, Matthew J. ;

Hartge, Patricia ;

Cerhan, James R. .

CANCER, 2010, 116 (12) :2993-3000

[9]

Gooley TA, 1999, STAT MED, V18, P695, DOI 10.1002/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.3.CO

[10]

2-F

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