Human Blood-Brain Barrier on a Chip: Featuring Unique Multicellular Cooperation in Pathophysiology

被引：10
作者：
Ahn, Song Ih [1 ,2 ,3 ]
Kim, YongTae [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA
[2] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA
[3] Mepsgenlab Inc, Atlanta, GA 30309 USA
[4] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
[5] Georgia Inst Technol, Inst Elect & Nanotechnol, Atlanta, GA 30332 USA
来源：
TRENDS IN BIOTECHNOLOGY | 2021年 / 39卷 / 08期
基金：
美国国家卫生研究院;
关键词：
PERICYTES;
D O I：
10.1016/j.tibtech.2021.01.010
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Advances in stem cell engineering have opened new avenues for more accurately developing in vitro models of the human blood-brain barrier (BBB). Here, we highlight state-of-the-art human BBB-on-a-chip technologies and discuss the importance of human brain cells for better modeling the human brain pathophysiology.
引用
收藏
页码：749 / 752
页数：4
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