Human Blood-Brain Barrier on a Chip: Featuring Unique Multicellular Cooperation in Pathophysiology

被引：10

作者：

Ahn, Song Ih ^{[1
,2
,3
]}

Kim, YongTae ^{[1
,2
,3
,4
,5
]}

机构：

[1] Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332 USA

[2] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA

[3] Mepsgenlab Inc, Atlanta, GA 30309 USA

[4] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[5] Georgia Inst Technol, Inst Elect & Nanotechnol, Atlanta, GA 30332 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2021年 / 39卷 / 08期

基金：

美国国家卫生研究院;

关键词：

PERICYTES;

D O I：

10.1016/j.tibtech.2021.01.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Advances in stem cell engineering have opened new avenues for more accurately developing in vitro models of the human blood-brain barrier (BBB). Here, we highlight state-of-the-art human BBB-on-a-chip technologies and discuss the importance of human brain cells for better modeling the human brain pathophysiology.

引用

页码：749 / 752

页数：4

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