Increased S100B serum levels in schizophrenic patients with tardive dyskinesia: Association with dyskinetic movements

被引：15

作者：

Zhang, Xiang Yang ^{[1
,2
]}

Xiu, Mei Hong ^{[2
]}

Chen, Da Chun ^{[2
]}

Zhu, Feng Yan ^{[2
]}

Wu, Gui Ying ^{[1
]}

Haile, Colin N. ^{[1
]}

Lu, Lin ^{[3
]}

Kosten, Therese A. ^{[1
]}

Kosten, Thomas R. ^{[1
]}

机构：

[1] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA

[2] Beijing HuiLongGuan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China

[3] Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2010年 / 44卷 / 07期

关键词：

Tardive dyskinesia; Schizophrenia; S100B; Antipsychotic treatment; S-100B PROTEIN; ANTIPSYCHOTICS; CLOZAPINE; BLOOD;

D O I：

10.1016/j.jpsychires.2009.10.012

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Several studies show that calcium-binding protein S100B is increased in schizophrenia and may be involved in the pathogenesis of tardive dyskinesia (TD). We therefore compared serum S100B levels in normal controls (n = 60), schizophrenic patients with (n = 32) and without TD (n = 50). Assessments included the abnormal involuntary movement scale (AIMS) and the positive and negative syndrome scale (PANSS). Serum S100B levels were measured by enzyme-linked immunosorbent assay (ELISA). The results indicated that patients with TD had higher serum S100B levels than normals and those without TD. Serum S100B levels were positively correlated with AIMS scores in patients with TD. These data suggest that increased S100B levels may be related to neuro-degeneration, associated with TO pathophysiology. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：429 / 433

页数：5

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