Tumor-directed dysregulation of erythroid progenitors drives immunosuppressive myeloid cells

被引：5

作者：

Mandula, Jessica K. ^{[1
]}

Rodriguez, Paulo C. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Immunol, Tampa, FL 33612 USA

来源：

CANCER CELL | 2022年 / 40卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.ccell.2022.04.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Long et al. demonstrate that tumors can reprogram erythroid progenitors into myeloid-erythroid cells that promote immunosuppression. Erythroid-differentiated myeloid cells (EDMCs) expand in cancer-bearing individuals, resemble the functionality of myeloid-derived suppressor cells (MDSCs), and correlate with poor response to immune-checkpoint inhibitors (ICIs) and tumor-related anemia.

引用

页码：597 / 599

页数：3

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