Activatable probes for diagnosis and biomarker detection by MRI

被引：43

作者：

Carril, Monica ^{[1
,2
]}

机构：

[1] CIC BiomaGUNE, Paseo Miramon 182, San Sebastian 20014, Spain

[2] Ikerbasque, Basque Fdn Sci, E-48011 Bilbao, Spain

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 23期

关键词：

MAGNETIC-RESONANCE SIGNALS; CONTRAST AGENTS; IN-VIVO; F-19; NMR; SILICA NANOPARTICLES; BETA-GALACTOSIDASE; ENZYMATIC-ACTIVITY; PROTEASE ACTIVITY; IMAGING SIGNALS; METAL-IONS;

D O I：

10.1039/c7tb00093f

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Magnetic resonance imaging (MRI) is a non-invasive imaging technique with widespread use in diagnosis. Frequently, contrast in MRI is enhanced with the aid of a contrast agent, among which smart, responsive, OFF/ON or activatable probes are of particular interest. These kinds of probes elicit a response to selective stimuli, evidencing the presence of enzymes or acidic pH, for instance. In this review, we will focus on smart probes that are detectable by both H-1 and F-19 MRI, frequently based on nanomaterials. We will discuss the triggering factors and the strategies employed thus far to activate each probe.

引用

页码：4332 / 4347

页数：16

共 79 条

[1] Nanoparticle-based probes to enable noninvasive imaging of proteolytic activity for cancer diagnosis [J].

Anani, Tareq ;

Panizzi, Peter ;

David, Allan E. .

NANOMEDICINE, 2016, 11 (15) :2007-2022

[2] What We Can Really Do with Bioresponsive MRI Contrast Agents [J].

Angelovski, Goran .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (25) :7038-7046

[3] Investigation of a Calcium-Responsive Contrast Agent in Cellular Model Systems: Feasibility for Use as a Smart Molecular Probe in Functional MRI [J].

Angelovski, Goran ;

Gottschalk, Sven ;

Milosevic, Milena ;

Engelmann, Joern ;

Hagberg, Gisela E. ;

Kadjane, Pascal ;

Andjus, Pavle ;

Logothetis, Nikos K. .

ACS CHEMICAL NEUROSCIENCE, 2014, 5 (05) :360-369

[4] Development of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy [J].

Ansari, Celina ;

Tikhomirov, Grigory A. ;

Hong, Su Hyun ;

Falconer, Robert A. ;

Loadman, Paul M. ;

Gill, Jason H. ;

Castaneda, Rosalinda ;

Hazard, Florette K. ;

Tong, Ling ;

Lenkov, Olga D. ;

Felsher, Dean W. ;

Rao, Jianghong ;

Daldrup-Link, Heike E. .

SMALL, 2014, 10 (03) :566-575

[5] Single 19F Probe for Simultaneous Detection of Multiple Metal Ions Using miCEST MRI [J].

Bar-Shir, Amnon ;

Yadav, Nirbhay N. ;

Gilad, Assaf A. ;

van Zijl, Peter C. M. ;

McMahon, Michael T. ;

Bulte, Jeff W. M. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (01) :78-81

[6] Concentration-independent MRI of pH with a dendrimer-based pH-responsive nanoprobe [J].

Bhuiyan, Mohammed P. I. ;

Aryal, Madhava P. ;

Janic, Branislava ;

Karki, Kishor ;

Varma, Nadimpalli R. S. ;

Ewing, James R. ;

Arbab, Ali S. ;

Ali, Meser M. .

CONTRAST MEDIA & MOLECULAR IMAGING, 2015, 10 (06) :481-486

[7] Fluorinated smart micelles as enzyme-responsive probes for 19F-magnetic resonance [J].

Buzhor, Marina ;

Avram, Liat ;

Frish, Limor ;

Cohen, Yoram ;

Amir, Roey J. .

JOURNAL OF MATERIALS CHEMISTRY B, 2016, 4 (18) :3037-3042

[8]

Chan KWY, 2013, NAT MATER, V12, P268, DOI [10.1038/NMAT3525, 10.1038/nmat3525]

[9] pH-Triggered Au-fluorescent mesoporous silica nanoparticles for 19F MR/fluorescent multimodal cancer cellular imaging [J].

Chen, Shizhen ;

Yang, Yuqi ;

Li, Haidong ;

Zhou, Xin ;

Liu, Maili .

CHEMICAL COMMUNICATIONS, 2014, 50 (03) :283-285

[10] Monitoring Phospholipase A2 Activity with Gd-encapsulated Phospholipid Liposomes [J].

Cheng, Zhiliang ;

Tsourkas, Andrew .

SCIENTIFIC REPORTS, 2014, 4

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