Activatable probes for diagnosis and biomarker detection by MRI

被引:43
作者
Carril, Monica [1 ,2 ]
机构
[1] CIC BiomaGUNE, Paseo Miramon 182, San Sebastian 20014, Spain
[2] Ikerbasque, Basque Fdn Sci, E-48011 Bilbao, Spain
关键词
MAGNETIC-RESONANCE SIGNALS; CONTRAST AGENTS; IN-VIVO; F-19; NMR; SILICA NANOPARTICLES; BETA-GALACTOSIDASE; ENZYMATIC-ACTIVITY; PROTEASE ACTIVITY; IMAGING SIGNALS; METAL-IONS;
D O I
10.1039/c7tb00093f
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Magnetic resonance imaging (MRI) is a non-invasive imaging technique with widespread use in diagnosis. Frequently, contrast in MRI is enhanced with the aid of a contrast agent, among which smart, responsive, OFF/ON or activatable probes are of particular interest. These kinds of probes elicit a response to selective stimuli, evidencing the presence of enzymes or acidic pH, for instance. In this review, we will focus on smart probes that are detectable by both H-1 and F-19 MRI, frequently based on nanomaterials. We will discuss the triggering factors and the strategies employed thus far to activate each probe.
引用
收藏
页码:4332 / 4347
页数:16
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