Bioactive lignans from Peperomia duclouxii

被引：44

作者：

Li, Na

Wu, Jian-lin

Hasegawa, Toshiaki

Sakai, Jun-ichi

Bai, Li-ming

Wang, Li-yan

Kakuta, Saori

Furuya, Yumiko

Ogura, Hirotsugu

Kataoka, Takao

Tomida, Akihiro

Tsuruo, Takashi

Ando, Masayoshi

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China

[2] Niigata Univ, Dept Chem & Chem Engn, Niigata 9502181, Japan

[3] Niigata Univ, Grad Sch Sci & Technol, Niigata 9502181, Japan

[4] Tokyo Inst Technol, Ctr Biol Resources & Informat, Midori Ku, Yokohama, Kanagawa 2268501, Japan

[5] Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Koto Ku, Tokyo 1358550, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 04期

关键词：

D O I：

10.1021/np0604533

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new lignans (1-6), along with 14 known compounds, were obtained from Peperomia duclouxii. The new structures were elucidated mainly by the analysis of their NMR and MS data. The absolute configurations of 1-6 were determined by comparing their optical rotations or CD spectra with those of known compounds. In cytotoxic and MDR reversal cell activity assays, compound 3 showed cancer cell growth inhibitory activity against VA-13 and HepG2 cells, with IC50 values of 5.3 and 13.2 mu g/mL, and more potent effects on calcein accumulation in MDR 2780AD cells than verapamil, a positive control. Compound 6 showed anti-inflammatory activity using an ICAM-1 assay (induction of the intercellular adhesion molecule-1), stimulated by IL-1 alpha and TNF-alpha.

引用

页码：544 / 548

页数：5

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