A human cell type similar to murine central nervous system perivascular fibroblasts

被引：7

作者：

Liu, Jianping ^{[1
]}

He, Liqun ^{[2
,3
]}

Muhl, Lars ^{[1
]}

Mocci, Giuseppe ^{[1
]}

Gustavsson, Sonja ^{[4
]}

Buyandelger, Byambajav ^{[4
]}

Vanlandewijck, Michael ^{[1
]}

Betsholtz, Christer ^{[2
]}

Westermark, Bengt ^{[2
]}

Andrae, Johanna ^{[2
]}

机构：

[1] Karolinska Inst, Dept Med Huddinge, Huddinge, Sweden

[2] Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Dag Hammarskjoldsvag 20, SE-75185 Uppsala, Sweden

[3] Tianjin Med Univ, Tianjin Neurol Inst, Dept Neurosurg,Gen Hosp,Minist Educ & Tianjin Cit, Key Lab Postneuroinjury Neuro Repair & Regenerat, Tianjin 300052, Peoples R China

[4] Karolinska Inst, Dept Med, Single Cell Core Facil, Huddinge, Sweden

来源：

EXPERIMENTAL CELL RESEARCH | 2021年 / 402卷 / 02期

基金：

中国国家自然科学基金; 瑞典研究理事会;

关键词：

Human; Murine; Brain; Perivascular; Fibroblast; RNA sequencing; FIBROTIC SCAR; FORM;

D O I：

10.1016/j.yexcr.2021.112576

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The brain vasculature has several specific features, one of them being the blood-brain barrier (BBB), which supports and protects the brain by allowing for the passage of oxygen and nutrients, while at the same time preventing passage of pathogens and toxins. The BBB also prevents efficient delivery of drugs to the brain, e.g. for treatment of brain tumors. In the murine brain, perivascular fibroblasts were recently identified as a novel potential constituent of the BBB. Here we present the existence of human cells that could be the equivalent to the murine brain perivascular fibroblasts. Using RNA sequencing, we show a similar transcriptomic profile of cultured human brain cells and murine perivascular fibroblasts. These data open up a window for new hypotheses on cell types involved in human CNS diseases.

引用

页数：8

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