Stereochemical diversity in pyrrolidine synthesis by catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

被引：130

作者：

Adrio, Javier ^{[1
,2
]}

Carretero, Juan C. ^{[1
,2
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Organ, E-28049 Madrid, Spain

[2] Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, E-28049 Madrid, Spain

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 80期

关键词：

SELECTIVE 3+2 CYCLOADDITION; NON-BIARYL ATROPISOMERS; ENANTIOSELECTIVE SYNTHESIS; CHIRAL CATALYSTS; COMPLEXES; CONSTRUCTION; DIASTEREO; PROLINE; ACCESS; DERIVATIVES;

D O I：

10.1039/c9cc05238k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pyrrolidine ring is a privileged structural motif in synthetic and medicinal chemisty. This review aims to highlight the high versatility of the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides for access to different types of stereochemical patterns in enantioselective pyrrolidine synthesis. Special attention will be paid to stereodivergent procedures giving rise to different stereoisomers from the same starting materials.

引用

页码：11979 / 11991

页数：13

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