Whole-Exome Sequencing Reveals Defective CYP3A4 Variants Predictive of Paclitaxel Dose-Limiting Neuropathy

被引：55

作者：

Apellaniz-Ruiz, Maria ^{[1
]}

Lee, Mi-Young ^{[2
]}

Sanchez-Barroso, Laras ^{[1
]}

Gutierrez-Gutierrez, Gerardo ^{[3
]}

Calvo, Isabel ^{[4
,5
]}

Garcia-Estevez, Laura ^{[5
]}

Sereno, Maria ^{[6
]}

Garcia-Donas, Jesus ^{[7
]}

Castelo, Beatriz ^{[8
]}

Guerra, Eva ^{[9
]}

Leandro-Garcia, Luis J. ^{[1
]}

Cascon, Alberto ^{[10
]}

Johansson, Inger ^{[2
]}

Robledo, Mercedes ^{[10
]}

Ingelman-Sundberg, Magnus ^{[2
]}

Rodriguez-Antona, Cristina ^{[1
,10
]}

机构：

[1] Spanish Natl Canc Res Ctr CNIO, Hereditary Endocrine Canc Grp, Madrid 28029, Spain

[2] Karolinska Inst, Dept Physiol & Pharmacol, Sect Pharmacogenet, Stockholm, Sweden

[3] Hosp Univ Infanta Sofia, Neurol Sect, Madrid, Spain

[4] Hosp Monteprincipe, Dept Med Oncol, Madrid, Spain

[5] Ctr Integral Oncol Clara Campal, Dept Med Oncol, Madrid, Spain

[6] Hosp Univ Infanta Sofia, Dept Med Oncol, Madrid, Spain

[7] Ctr Integral Oncol Clara Campal, Gynecol & Genitourinary Tumors Programme, Madrid, Spain

[8] Hosp Univ La Paz, Dept Med Oncol, Madrid, Spain

[9] Hosp Univ Ramon & Cajal, Dept Med Oncol, Madrid, Spain

[10] ISCIII Ctr Biomed Res Rare Dis CIBERER, Madrid, Spain

来源：

CLINICAL CANCER RESEARCH | 2015年 / 21卷 / 02期

关键词：

GENOME-WIDE ASSOCIATION; PERIPHERAL NEUROPATHY; CANCER-PATIENTS; RARE VARIANTS; PHARMACOKINETICS; PHARMACOGENOMICS; IDENTIFICATION; POWER; TOOL;

D O I：

10.1158/1078-0432.CCR-14-1758

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：322 / 328

页数：7

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