Antioxidant Profile of Hyaluronan: Physico-Chemical Features and its Role in Pathologies

被引：24

作者：

Mendoza, G. ^{[1
]}

Prieto, J. G. ^{[1
]}

Real, R. ^{[1
]}

Perez, M. ^{[1
]}

Merino, G. ^{[1
]}

Alvarez, A. I. ^{[1
]}

机构：

[1] Univ Leon, Dept Biomed Sci, E-24071 Leon, Spain

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 13期

关键词：

Hyaluronan; antioxidants; reactive oxygen species; oxidative damage; inflammation; therapeutic use; MOLECULAR-WEIGHT HYALURONAN; EXTRACELLULAR-SUPEROXIDE DISMUTASE; BOVINE ARTICULAR CHONDROCYTES; COLLAGEN-INDUCED ARTHRITIS; HUMAN SYNOVIAL FIBROBLASTS; MOLAR-MASS HYALURONAN; FREE-RADICALS; NITRIC-OXIDE; PROINFLAMMATORY CYTOKINES; RHEUMATOID-ARTHRITIS;

D O I：

10.2174/138955709790361494

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Many findings have evidenced antioxidant properties of hyaluronan, both in vitro and in vivo, by means of which it can scavenge free radicals and exert its effect on pathologies. The aim of this review is to summarize the available data on the features and clinical profile of hyaluronan, with regard in particular to its antioxidant capacity and to its related physico-chemical properties. Additionally, hyaluronan and its derivatives are examined, with the focus on their therapeutic uses, protection against cellular damage, and their role as inflammatory mediators. Finally, therapies associated to the antioxidant effect of hyaluronan are discussed.

引用

页码：1479 / 1488

页数：10

共 104 条

[1] Intronic splicing of hyaluronan synthase 1 (HAS1):: a biologically relevant indicator of poor outcome in multiple myeloma [J].