Fast production of highly concentrated reactive [18F] fluoride for aliphatic and aromatic nucleophilic radiolabelling

被引：39

作者：

Aerts, Joel ^{[1
]}

Voccia, Samuel ^{[2
]}

Lemaire, Christian ^{[1
]}

Giacomelli, Fabrice ^{[1
]}

Goblet, David ^{[1
]}

Thonon, David ^{[1
]}

Plenevaux, Alain ^{[1
]}

Warnock, Geoffrey ^{[1
]}

Luxen, Andre ^{[1
]}

机构：

[1] Univ Liege, Ctr Rech Cyclotron, B-4000 Liege, Belgium

[2] Trasis SA, B-4053 Embourg, Belgium

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 01期

关键词：

Radiofluorination; Radiopharmaceuticals; Fluoride; F-18; Nucleophilic substitution; Positron emission tomography; SPE; NO-CARRIER; LOW POLARITY; FLUORINATION; PET;

D O I：

10.1016/j.tetlet.2009.10.085

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of a polymeric solid support loaded with a long alkyl chain quaternary ammonium allows the rapid and efficient recovery of cyclotron produced [F-18]F- from [O-18]water to a low water content organic solution compatible with fast nucleophilic labelling of most precursors for PET radiopharmaceuticals in high yield. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：64 / 66

页数：3

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