Central nervous system relapse in acute promyelocytic leukaemia in patients treated with all-trans retinoic acid

被引：39

作者：

Evans, G

Grimwade, D

Prentice, HG

Simpson, N

机构：

[1] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

[2] IPSWICH HOSP,DEPT HAEMATOL,IPSWICH,SUFFOLK,ENGLAND

[3] ROYAL FREE HOSP,DEPT HAEMATOL,LONDON NW3 2QG,ENGLAND

[4] UNIV LONDON SCH MED,LONDON,ENGLAND

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1997年 / 98卷 / 02期

关键词：

APL; ATRA; extramedullary relapse;

D O I：

10.1046/j.1365-2141.1997.2333050.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

All-trans retinoic acid (ATRA) is currently recommended as standard treatment for acute promyelocytic leukaemia (APL). However, there has been increasing concern that ATRA is associated with unusual sites of relapse. We present three cases of APL previously treated with ATRA who ultimately relapsed within the central nervous system (CNS) and hypothesize that, by up-regulating intercellular adhesion molecules, ATRA may facilitate the passage of malignant promyelocytes across the blood-brain barrier.

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收藏

页码：437 / 439

页数：3

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